Iwata Hisataka
Tokyo University of Agriculture Funako 1737243-034 Atsugi Kanagawa Japan.
Reprod Med Biol. 2016 Jan 8;15(3):155-164. doi: 10.1007/s12522-015-0233-5. eCollection 2016 Jul.
Maternal aging profoundly affects oocyte quality. This has become common knowledge in industrialized countries and extensive studies addressing the causes and possible countermeasures against age-associated deterioration of oocytes suggest that mitochondrial dysfunction is a causal factor in infertility. However, almost all studies addressing age-associated events in oocytes have used mice as an animal model, and the reproductive life of mice is very short, making it difficult to study the gradual decline in fertility observed in humans. In the present review, age-associated changes in the quality and quantity of bovine oocytes and possible countermeasures related to mitochondrial quality control are introduced.
母体衰老会深刻影响卵母细胞质量。这在工业化国家已成为常识,针对卵母细胞与年龄相关的衰退原因及可能的应对措施进行的大量研究表明,线粒体功能障碍是导致不孕的一个因素。然而,几乎所有针对卵母细胞与年龄相关事件的研究都以小鼠作为动物模型,而小鼠的生殖寿命非常短,这使得研究人类中观察到的生育能力逐渐下降变得困难。在本综述中,介绍了牛卵母细胞质量和数量与年龄相关的变化以及与线粒体质量控制相关的可能应对措施。