Australian Centre for Vaccine Development, Queensland Institute of Medical Research, Brisbane, Queensland, Australia.
Immunol Cell Biol. 2011 Mar;89(3):352-8. doi: 10.1038/icb.2010.136. Epub 2011 Feb 8.
Human herpesviruses have coevolved with humans over millions of years, and adaptation of latent infection within the cells of the immune system is a unique characteristic of many of these viruses. Following primary infection, these herpesviruses establish an asymptomatic-persistent infection in healthy individuals that is strictly controlled by virus-specific CD8(+) and CD4(+) T cells. Here, we provide a brief overview of how the human immune system interacts with these latent viruses and regulates the lifelong host-virus relationship in healthy virus carriers. Extensive studies on T-cell-mediated immune regulation over the last decade has allowed researchers to successfully translate these findings into the clinical setting to treat various herpesvirus-associated diseases in transplant patients and individuals with virus-associated malignancies. It is highly likely that these newly emerging T-cell-based therapeutic and diagnostic technologies will revolutionize the clinical management of patients with herpesvirus-associated diseases.
人类疱疹病毒在数百万年的时间里与人类共同进化，其在免疫系统细胞中的潜伏感染适应性是许多此类病毒的独特特征。在原发感染后，这些疱疹病毒在健康个体中建立无症状持续性感染，这种感染受到病毒特异性 CD8(+)和 CD4(+)T 细胞的严格控制。在这里，我们简要概述了人类免疫系统如何与这些潜伏病毒相互作用，并调节健康病毒携带者的终生宿主-病毒关系。在过去十年中，对 T 细胞介导的免疫调节的广泛研究使研究人员能够成功地将这些发现转化到临床环境中，以治疗移植患者和病毒相关性恶性肿瘤患者的各种疱疹病毒相关疾病。这些新出现的基于 T 细胞的治疗和诊断技术极有可能彻底改变疱疹病毒相关疾病患者的临床管理。
