Rouse B T, Babiuk L A
Can J Comp Med. 1978 Oct;42(4):414-27.
A variety of specific immunological mechanisms have been shown to be effective at neutralizing herpesviruses or destroying herpesvirus infected cells. These include both humoral and cell mediated immune responses or combinations thereof. Thus, it is genarlly accepted that humoral immunity is probably responsible for preventing reinfection whereas cellular immunity, mediated by T lymphocytes or by the interaction of antibody and Fc receptor bearing cells, is more important in recovery from infections. In addition to these specific responses to herpesvirus infection, a number of nonspecific cellular and humoral components have been shown to inhibit the progression of virus replication and therefore, have been implicated in assisting the host in the recovery process. The various interactions and counteractions between the various nonspecific and specific components of the immune response are discussed with respect to their role in recovery from both primary and recurrent disease as well as how they may eventually be manipulated so as to control herpesvirus recrudescent disease.
多种特定免疫机制已被证明在中和疱疹病毒或破坏受疱疹病毒感染的细胞方面有效。这些机制包括体液免疫和细胞介导的免疫反应或两者的组合。因此，人们普遍认为体液免疫可能负责预防再感染，而由T淋巴细胞介导或由抗体与携带Fc受体的细胞相互作用介导的细胞免疫在感染恢复中更为重要。除了对疱疹病毒感染的这些特异性反应外，一些非特异性细胞和体液成分已被证明可抑制病毒复制的进展，因此，它们被认为在协助宿主恢复过程中发挥作用。本文讨论了免疫反应中各种非特异性和特异性成分之间的各种相互作用和反作用，涉及它们在原发性和复发性疾病恢复中的作用，以及最终如何对它们进行调控以控制疱疹病毒复发疾病。
