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导向氮亲核试剂至中间位置：钯催化的异氰酸酯与 2-亚烷基三亚甲基碳酸酯的脱羧环丙烷化反应。

Guiding the nitrogen nucleophile to the middle: palladium-catalyzed decarboxylative cyclopropanation of 2-alkylidenetrimethylene carbonates with isocyanates.

机构信息

Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502, Japan.

出版信息

Chem Commun (Camb). 2011 Mar 21;47(11):3057-9. doi: 10.1039/c0cc05308b. Epub 2011 Feb 8.

DOI:10.1039/c0cc05308b
PMID:21301754
Abstract

A palladium-catalyzed decarboxylative cyclopropanation of 2-alkylidenetrimethylene carbonates with isocyanates is described to form oxazolidinones of (1-aminocyclopropyl)methanols with high selectivity. The site of nucleophilic attack is directed by connecting the two reaction components and by employing an electron-deficient triarylphosphine ligand.

摘要

描述了钯催化的 2-亚烷基三亚甲基碳酸酯与异氰酸酯的脱羧环丙烷化反应，以高选择性形成（1-氨基环丙基）甲醇的恶唑烷酮。亲核进攻的位置通过连接两个反应组分和使用缺电子的三芳基膦配体来导向。

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