鸡 B 系统中免疫反应基因与血清学决定抗原之间的重组。
Recombination between genes coding for immune response and the serologically determined antigens in the chickenB system.
机构信息
Department of Animal Science, Iowa State University, 50011, Ames, Iowa.
出版信息
Immunogenetics. 1978 Dec;7(1):25-33. doi: 10.1007/BF01843984.
Evidence is presented for a crossover between the genes coding for the serologically determined (SD) antigens on erythrocytes and an immune response gene (Ir-GAT) controlling immune response to the synthetic polypeptide GAT within theB complex, the MHC of chickens. TheIr-GAT (1) andIr-GAT (19) alleles control low and high immune response to GAT, respectively. Both low and high responders were recovered as recombinants fromB (1) B (1) andB (19) B (19) birds. The low-responder haplotypes are homozygous for theIr-GAT (1) allele and the high-responder haplotypes carry theIr-GAT (19) allele. Mortality forB (1) B (1) nonresponder birds was 39%, compared with 19% for theB (1) B (1) high responders; this suggests the possibility that genes located within the immune response region of theB complex exert some genetic control over viability and survival.
证据表明，红细胞上血清学确定（SD）抗原的编码基因与控制对 MHC 中合成多肽 GAT 免疫反应的免疫反应基因（Ir-GAT）之间存在交叉。Ir-GAT（1）和 Ir-GAT（19）等位基因分别控制对 GAT 的低和高免疫反应。低和高反应者均从 B（1）B（1）和 B（19）B（19）鸟类中作为重组体回收。低反应者的单倍型为 Ir-GAT（1）等位基因纯合，高反应者的单倍型携带 Ir-GAT（19）等位基因。B（1）B（1）无反应者的死亡率为 39%，而 B（1）B（1）高反应者为 19%；这表明 MHC 中免疫反应区域内的基因可能对生存能力和存活率有一定的遗传控制。
Zotero 插件