B淋巴细胞免疫反应基因表型是由基因决定的。
B lymphocyte immune response gene phenotype is genetically determined.
作者信息
Tse H Y, Mond J J, Longo D L
出版信息
J Exp Med. 1982 Apr 1;155(4):1239-44. doi: 10.1084/jem.155.4.1239.
Abstract
We examined the effects of the developmental milieu on the capacity of B cells to undergo immune response gene-controlled, T cell-dependent polyclonal proliferation. Although I-Aq poly(Glu60 Ala30 Tyr10)n (GAT)-nonresponder T cells developing in a responder environment become phenotypic GAT-responders, I-Aq B cells remain unresponsive to GAT, even after maturation in a GAT-responder animal. Conversely, (B10.A x B10.Q)F1 ([GAT responder x GAT nonresponder]F1) T cells developing in a B10.Q GAT nonresponder host fail to respond to GAT, but F1 B cells from the same F1 leads to parent chimeras make excellent proliferative responses in the presence of GAT and responder T cells. Thus, by this assay, B cell immune response gene function is genetically determined and is not affected by the developmental milieu.
摘要
我们研究了发育环境对B细胞进行免疫应答基因控制的、T细胞依赖性多克隆增殖能力的影响。尽管在应答者环境中发育的I-Aq多聚（Glu60 Ala30 Tyr10）n（GAT）无反应性T细胞会变成表型上的GAT反应者，但I-Aq B细胞即使在GAT反应者动物体内成熟后，对GAT仍无反应。相反，在B10.Q GAT无反应性宿主中发育的（B10.A×B10.Q）F1（[GAT反应者×GAT无反应者]F1）T细胞对GAT无反应，但来自同一F1与亲代嵌合体的F1 B细胞在有GAT和反应性T细胞存在的情况下能产生良好的增殖反应。因此，通过该检测方法，B细胞免疫应答基因功能是由基因决定的，不受发育环境的影响。
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B lymphocyte immune response gene phenotype is genetically determined.B淋巴细胞免疫反应基因表型是由基因决定的。
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Antigen presentation in the murine T lymphocyte proliferative response. II. Ir-GAT-controlled T lymphocyte responses require antigen-presenting cells from a high responder donor.小鼠T淋巴细胞增殖反应中的抗原呈递。II. Ir-GAT控制的T淋巴细胞反应需要来自高反应性供体的抗原呈递细胞。
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本文引用的文献
1
Antigen recognition. V. Requirement for histocompatibility between antigen-presenting cell and B cell in the response to a thymus-dependent antigen, and lack of allogeneic restriction between T and B cells.抗原识别。V. 对胸腺依赖性抗原应答中抗原呈递细胞与B细胞之间组织相容性的要求，以及T细胞与B细胞之间缺乏同种异体限制。
J Exp Med. 1981 Sep 1;154(3):676-87. doi: 10.1084/jem.154.3.676.
2
Selective loss of antigen-specific Ir gene function in IA mutant B6.C-H-2bm12 is an antigen presenting cell defect.IA突变体B6.C-H-2bm12中抗原特异性Ir基因功能的选择性丧失是一种抗原呈递细胞缺陷。
Proc Natl Acad Sci U S A. 1981 Oct;78(10):6406-10. doi: 10.1073/pnas.78.10.6406.
3
T lymphocyte-dependent B lymphocyte proliferative response to antigen. I Genetic restriction of the stimulation of B lymphocyte proliferation.T淋巴细胞依赖性B淋巴细胞对抗原的增殖反应。I. B淋巴细胞增殖刺激的遗传限制
J Exp Med. 1981 Apr 1;153(4):871-82. doi: 10.1084/jem.153.4.871.
4
Inhibition of antigen-induced proliferation of T cells from radiation-induced bone marrow chimeras by a monoclonal antibody directed against an Ia determinant on the antigen-presenting cell.一种针对抗原呈递细胞上Ia决定簇的单克隆抗体对辐射诱导骨髓嵌合体中T细胞抗原诱导增殖的抑制作用。
Proc Natl Acad Sci U S A. 1981 Jan;78(1):514-8. doi: 10.1073/pnas.78.1.514.
5
Monoclonal antibody against an Ir gene product?针对免疫反应基因产物的单克隆抗体？
J Exp Med. 1980 Oct 1;152(4):1085-101. doi: 10.1084/jem.152.4.1085.
6
Cell interactions between histoincompatible T and B lymphocytes. VII. Cooperative responses between lymphocytes are controlled by genes in the I region of the H-2 complex.组织相容性不相容的T淋巴细胞和B淋巴细胞之间的细胞相互作用。VII.淋巴细胞之间的协同反应受H-2复合体I区基因的控制。
J Exp Med. 1975 Jan 1;141(1):263-8. doi: 10.1084/jem.141.1.263.
7
Lymphoid function in F1 leads to parent chimeras: lack of evidence for adaptive differentiation of B cells or antigen-presenting cells.F1中的淋巴细胞功能导致亲代嵌合体：缺乏B细胞或抗原呈递细胞适应性分化的证据。
J Exp Med. 1979 Sep 19;150(3):715-20. doi: 10.1084/jem.150.3.715.
8
H-2 antigens of the thymus determine lymphocyte specificity.胸腺的H-2抗原决定淋巴细胞特异性。
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9
Adaptive differentiation of murine lymphocytes. I. Both T and B lymphocytes differentiating in F1 transplanted to parental chimeras manifest preferential cooperative activity for partner lymphocytes derived from the same parental type corresponding to the chimeric host.小鼠淋巴细胞的适应性分化。I. 移植到亲代嵌合体中的F1代中分化的T淋巴细胞和B淋巴细胞，对源自与嵌合宿主相对应的同一亲代类型的伙伴淋巴细胞均表现出优先的协同活性。
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Restricted helper function of F1 leads to parent bone marrow chimeras controlled by K-end of H-2 complex.F1的受限辅助功能导致由H-2复合体的K端控制的亲代骨髓嵌合体。
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