体外免疫反应的遗传控制。IV. 在体外Ir基因控制下抗体反应发生过程中，无反应亲代B细胞与致敏（有反应加无反应）F1 T细胞之间协同相互作用的条件。
Genetic control of immune responses in vitro. IV. Conditions for cooperative interactions between nonresponder parental B cells and primed (responder plus nonresponder) F1 T cells in the development of an antibody response under Ir gene control in vitro.
作者信息
Benacerraf B, Kapp J A, Pierce C W, Katz D H
出版信息
J Exp Med. 1974 Jul 1;140(1):185-98. doi: 10.1084/jem.140.1.185.
Abstract
The conditions for cooperative interactions between nonresponder B10.S B cells and GAT-primed irradiated (C57BL/6 x SJL)F(1) T cells in the response by cultures of mouse spleen cells to GAT were investigated. GAT-specific antibody responses could be elicited by soluble GAT in cultures of GAT-primed irradiated (C57BL/6 x SJL)F(1) T cells with C57BL/6 B cells but not with B10.S B cells. In contrast, when GAT was presented to the cultures on F(1) macrophages or as aggregates of GAT with MBSA, GAT-specific PFC responses were observed with both B10.S or C57BL/6 B cells. Irradiated GAT-primed T cells were nevertheless essential for the development of these responses. The GAT-specific response of B10.S B cells in these cultures was inhibited by the addition of soluble GAT at culture initiation. These results indicate that genetic disparity at Ir loci is not an absolute barrier to T-B-cell cooperative interactions in the response to antigens under Ir gene control. The significance of these data for the function of Ir gene products in immunocompetent cells is discussed.
摘要
研究了在小鼠脾细胞培养物对谷氨酸-丙氨酸-酪氨酸（GAT）的应答中，无反应性B10.S B细胞与经GAT致敏的辐照（C57BL/6×SJL）F1 T细胞之间合作相互作用的条件。在经GAT致敏的辐照（C57BL/6×SJL）F1 T细胞与C57BL/6 B细胞的培养物中，可溶性GAT可引发GAT特异性抗体应答，但与B10.S B细胞则不能。相反，当GAT以F1巨噬细胞呈递给培养物或作为GAT与甲基化牛血清白蛋白（MBSA）的聚集体时，B10.S或C57BL/6 B细胞均观察到GAT特异性的空斑形成细胞（PFC）应答。不过，经辐照的GAT致敏T细胞对于这些应答的发生是必不可少的。在培养开始时添加可溶性GAT可抑制这些培养物中B10.S B细胞的GAT特异性应答。这些结果表明，Ir基因座上的遗传差异并非是Ir基因控制下对抗原应答中T-B细胞合作相互作用的绝对障碍。讨论了这些数据对于免疫活性细胞中Ir基因产物功能的意义。
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Genetic control of immune responses in vitro. IV. Conditions for cooperative interactions between nonresponder parental B cells and primed (responder plus nonresponder) F1 T cells in the development of an antibody response under Ir gene control in vitro.体外免疫反应的遗传控制。IV. 在体外Ir基因控制下抗体反应发生过程中，无反应亲代B细胞与致敏（有反应加无反应）F1 T细胞之间协同相互作用的条件。
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The affinity of the reticulo-endothelial system for various modified serum proteins.网状内皮系统对各种修饰血清蛋白的亲和力。
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Cell interactions between histoincompatible T and B lymphocytes. IV. Involvement of the immune response (Ir) gene in the control of lymphocyte interactions in responses controlled by the gene.组织相容性不相容的T淋巴细胞与B淋巴细胞之间的细胞相互作用。IV. 免疫反应（Ir）基因在由该基因控制的反应中对淋巴细胞相互作用的控制作用。
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Immunological tolerance in bone marrow-derived lymphocytes. 3. Tolerance induction in primed B cells by hapten conjugates of unrelated immunogenic or "nonimmunogenic" carriers.骨髓来源淋巴细胞中的免疫耐受。3. 无关免疫原性或“非免疫原性”载体的半抗原缀合物对已致敏B细胞的耐受诱导。
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Genetic control of immune responses in vitro. II. Cellular requirements for the development of primary plaque-forming cell responses to the random terpolymer 1-glutamic acid 60-1-alanine30-1-tyrosine10 (GAT) by mouse spleen cells in vitro.体外免疫反应的遗传控制。II. 小鼠脾细胞在体外对随机三聚物1-谷氨酸60-1-丙氨酸30-1-酪氨酸10（GAT）产生原发性噬斑形成细胞反应的细胞条件。
J Exp Med. 1973 Nov 1;138(5):1121-32. doi: 10.1084/jem.138.5.1121.
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