Pacific Institute of Bioorganic Chemistry of Far Eastern Branch of the Russian Academy of Sciences, Vladivostok, 690022, Russia.
Appl Biochem Biotechnol. 2011 Jul;164(6):841-50. doi: 10.1007/s12010-011-9178-2. Epub 2011 Feb 8.
Fucoidans were isolated by water extraction and ion-exchange chromatography from brown algae Eclonia cava, Sargassum hornery, and Costaria costata collected near of Korean coasts. The structures of fucoidans were investigated. Fucoidan from E. cava was mixture of sulfated rhamnogalactofucan and galactofucan. Fucoidan from C. costata was a sulfated galactofucan. Fucoidan isolated from S. hornery was separated into three fractions: a homofucan sulfate, a homofucan but without sulfate groups, and a sulfated rhamnofucan. The results clearly showed that fucoidans play an inhibitory role in colony formation in human melanoma and colon cancer cells and may be effective antitumor agents.
褐藻岩藻聚糖、角叉菜聚糖和缘管马尾藻聚糖分别从韩国海域附近采集的褐藻昆布、角叉菜和缘管马尾藻中用水提和离子交换色谱法分离得到。对褐藻聚糖的结构进行了研究。昆布来源的岩藻聚糖是硫酸化鼠李半乳糖醛酸聚糖和半乳糖醛酸聚糖的混合物。缘管马尾藻来源的褐藻聚糖是硫酸化半乳糖醛酸聚糖。从角叉菜中分离得到的褐藻聚糖被分离成三个部分：硫酸化岩藻糖硫酸酯、无硫酸基团的岩藻糖聚糖和硫酸化鼠李半乳糖醛酸聚糖。结果清楚地表明，褐藻聚糖在人黑色素瘤和结肠癌细胞的集落形成中发挥抑制作用，可能是有效的抗肿瘤药物。
