Computational Life Science Cluster-CLiC, Department of Chemistry, Umeå University, SE-90187 Umeå, Sweden.
Arthritis Res Ther. 2011 Feb 8;13(1):R19. doi: 10.1186/ar3243.
The aim of this study was to assess the feasibility of diagnosing early rheumatoid arthritis (RA) by measuring selected metabolic biomarkers.
We compared the metabolic profile of patients with RA with that of healthy controls and patients with psoriatic arthritis (PsoA). The metabolites were measured using two different chromatography-mass spectrometry platforms, thereby giving a broad overview of serum metabolites. The metabolic profiles of patient and control groups were compared using multivariate statistical analysis. The findings were validated in a follow-up study of RA patients and healthy volunteers.
RA patients were diagnosed with a sensitivity of 93% and a specificity of 70% in a validation study using detection of 52 metabolites. Patients with RA or PsoA could be distinguished with a sensitivity of 90% and a specificity of 94%. Glyceric acid, D-ribofuranose and hypoxanthine were increased in RA patients, whereas histidine, threonic acid, methionine, cholesterol, asparagine and threonine were all decreased compared with healthy controls.
Metabolite profiling (metabolomics) is a potentially useful technique for diagnosing RA. The predictive value was without regard to the presence of antibodies against cyclic citrullinated peptides.
本研究旨在评估通过测量特定代谢生物标志物诊断早期类风湿关节炎（RA）的可行性。
我们比较了 RA 患者、银屑病关节炎（PsoA）患者和健康对照组的代谢谱。使用两种不同的色谱-质谱平台测量代谢物，从而全面了解血清代谢物。使用多变量统计分析比较患者组和对照组的代谢谱。在 RA 患者和健康志愿者的后续研究中对结果进行了验证。
在使用检测 52 种代谢物的验证研究中，RA 患者的诊断敏感性为 93%，特异性为 70%。RA 或 PsoA 患者的敏感性为 90%，特异性为 94%。RA 患者的甘油酸、D-核糖呋喃糖和次黄嘌呤升高，而与健康对照组相比，组氨酸、苏糖醇、蛋氨酸、胆固醇、天冬酰胺和苏氨酸均降低。
代谢组学（代谢组学）是一种用于诊断 RA 的潜在有用技术。该预测值与环瓜氨酸肽抗体的存在无关。
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