Department of Metabolism and Nutrition, Institute of Food Science and Technology and Nutrition (ICTAN), Spanish National Research Council (CSIC), C/José Antonio Novais 10, 28040 Madrid, Spain.
Br J Nutr. 2011 Jun;105(11):1652-9. doi: 10.1017/S0007114510005490. Epub 2011 Feb 8.
Fe-deficiency anaemia is a worldwide health problem. We studied the influence of consuming an Fe-fortified fruit juice on Fe status in menstruating women. A randomised, double-blind, placebo-controlled study of 16 weeks of duration was performed. Subjects were randomised into two groups: the P group (n 58) or the F group (n 64), and consumed, as a supplement to their usual diet, 500 ml/d of a placebo fruit juice or an Fe-fortified fruit juice, respectively. The Fe-fortified fruit juice, containing microencapsulated iron pyrophosphate, provided 18 mg Fe/d (100 % of the RDA). At baseline and monthly, dietary intake, body weight and Fe parameters were determined: total erythrocytes, haematocrit, mean corpuscular volume (MCV), red blood cell distribution width (RDW), Hb, serum Fe, serum ferritin, serum transferrin, transferrin saturation, soluble transferrin receptor (sTfR) and zinc protoporphyrin (ZnPP). The fruit juice consumption involved increased intake of carbohydrates and vitamin C, and increased BMI within normal limits. Ferritin was higher in the F group after week 4 (P < 0·05) and became 80 % higher than in the P group after week 16 (P < 0·001), and transferrin decreased in the F group compared with the P group after week 4 (P < 0·001). RDW was higher at weeks 4 and 8 in the F group compared with the P group (P < 0·05). Transferrin saturation increased after week 8, and haematocrit, MCV and Hb increased after week 12, in the F group compared with the P group. Serum Fe did not change. sTfR and ZnPP decreased in the F group at week 16 (P < 0·05). Iron pyrophosphate-fortified fruit juice improves Fe status and may be used to prevent Fe-deficiency anaemia.
缺铁性贫血是一个全球性的健康问题。我们研究了饮用铁强化果汁对月经期妇女铁状况的影响。进行了一项为期 16 周的随机、双盲、安慰剂对照研究。受试者被随机分为两组：P 组（n 58）或 F 组（n 64），并分别作为其日常饮食的补充，每天饮用 500 毫升安慰剂果汁或铁强化果汁。铁强化果汁含有微胶囊化焦磷酸铁，每天提供 18 毫克铁（占 RDA 的 100%）。在基线和每月时，测定膳食摄入量、体重和铁参数：总红细胞、血细胞比容、平均红细胞体积（MCV）、红细胞分布宽度（RDW）、Hb、血清铁、血清铁蛋白、血清转铁蛋白、转铁蛋白饱和度、可溶性转铁蛋白受体（sTfR）和锌原卟啉（ZnPP）。果汁的摄入增加了碳水化合物和维生素 C 的摄入，并使 BMI 在正常范围内增加。F 组在第 4 周（P < 0·05）后 ferritin 升高，并在第 16 周（P < 0·001）后 ferritin 比 P 组升高 80%，F 组在第 4 周（P < 0·001）后转铁蛋白降低与 P 组相比。与 P 组相比，F 组在第 4 周和第 8 周时 RDW 较高（P < 0·05）。F 组在第 8 周后转铁蛋白饱和度升高，第 12 周后血细胞比容、MCV 和 Hb 升高与 P 组相比。血清铁没有变化。F 组在第 16 周时 sTfR 和 ZnPP 下降（P < 0·05）。焦磷酸铁强化果汁可改善铁状况，可用于预防缺铁性贫血。
