社会认知、执行功能以及共情缺陷在额颞叶痴呆中的神经影像学相关性。
Social cognition, executive functioning, and neuroimaging correlates of empathic deficits in frontotemporal dementia.
机构信息
Department of Neurology, EC037, PA State Hershey Medical Center, P.O. Box 850, Hershey, PA 17033-0850, USA.
出版信息
J Neuropsychiatry Clin Neurosci. 2011 Winter;23(1):74-82. doi: 10.1176/jnp.23.1.jnp74.
Abstract
The authors investigated aspects of interpersonal sensitivity and perspective-taking in relation to empathy, social cognitions, and executive functioning in 26 frontotemporal dementia (FTD) patients. Behavioral-variant FTD (bvFTD) patients were significantly impaired on caregiver assessments of empathy, although self-ratings were normal. Progressive nonfluent aphasia and semantic-dementia samples were rarely abnormal. In bvFTD, empathy ratings were found to be correlated with social cognition and executive functioning measures, but not depression. Voxel-based morphometry revealed that reduced empathic perspective-taking was related to bifrontal and left anterior temporal atrophy, whereas empathic emotions were related to right medial frontal atrophy. Findings suggest that bvFTD causes multiple types of breakdown in empathy, social cognition, and executive resources, mediated by frontal and temporal disease.
摘要
作者研究了人际敏感性和换位思考与共情、社会认知和执行功能的关系，涉及 26 名额颞叶痴呆（FTD）患者。行为变异型额颞叶痴呆（bvFTD）患者在照顾者对共情的评估中表现出明显的障碍，尽管自我评估正常。进行性非流利性失语症和语义性痴呆样本很少异常。在 bvFTD 中，共情评估与社会认知和执行功能测量相关，但与抑郁无关。基于体素的形态测量学显示，共情视角的减少与额极和左侧前颞叶萎缩有关，而共情情绪与右侧内侧额叶萎缩有关。研究结果表明，bvFTD 导致共情、社会认知和执行资源的多种类型崩溃，由额叶和颞叶疾病介导。
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