磷脂酸磷酸水解酶和磷脂酶A活性在肝脏甘油脂质合成调控中的作用。葡萄糖、果糖、山梨醇、甘油和乙醇急性喂食的影响。
The involvement of phosphatidate phosphohydrolase and phospholipase A activities in the control of hepatic glycerolipid synthesis. Effects of acute feeding with glucose, fructose, sorbitol, glycerol and ethanol.
作者信息
Sturton R G, Pritchard P H, Han L Y, Brindley D N
出版信息
Biochem J. 1978 Aug 15;174(2):667-70. doi: 10.1042/bj1740667.
Abstract
Rats were fed by stomach tube with a single dose of glucose, sorbitol, fructose, glycerol or ethanol of equivalent energy contents or with 0.15 M-NaCl. They were killed 6 h later and the relative rates of phosphatidate deacylation and dephosphorylation measured in the microsomal and supernatant fractions of the livers. Treatment with sorbitol, fructose, glycerol and ethanol increased phosphohydrolase activities in the microsomal and supernatant fractions. The only significant change in deacylase activity was an increase in the microsomal fraction produced by ethanol. It is proposed that hepatic triacylglycerol synthesis is partly controlled by the balance between phosphatidate phosphohydrolase and phospholipase A-type activities.
摘要
通过胃管给大鼠单剂量喂食能量含量相当的葡萄糖、山梨醇、果糖、甘油或乙醇，或0.15 M氯化钠。6小时后将它们处死，并测定肝脏微粒体和上清液部分中磷脂酸脱酰基和去磷酸化的相对速率。用山梨醇、果糖、甘油和乙醇处理可增加微粒体和上清液部分中的磷酸水解酶活性。脱酰酶活性唯一显著的变化是乙醇使微粒体部分增加。有人提出，肝脏三酰甘油的合成部分受磷脂酸磷酸水解酶和磷脂酶A类活性之间平衡的控制。
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The involvement of phosphatidate phosphohydrolase and phospholipase A activities in the control of hepatic glycerolipid synthesis. Effects of acute feeding with glucose, fructose, sorbitol, glycerol and ethanol.磷脂酸磷酸水解酶和磷脂酶A活性在肝脏甘油脂质合成调控中的作用。葡萄糖、果糖、山梨醇、甘油和乙醇急性喂食的影响。
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