肝脏三酰甘油合成的调控。大鼠肝脏磷脂酸磷酸水解酶活性以及循环胰岛素和皮质酮浓度的昼夜变化。
Control of hepatic triacylglycerol synthesis. Diurnal variations in hepatic phosphatidate phosphohydrolase activity and in the concentrations of circulating insulin and corticosterone in rats.
作者信息
Knox A M, Sturton R G, Cooling J, Brindley D N
出版信息
Biochem J. 1979 May 15;180(2):441-3. doi: 10.1042/bj1800441.
Abstract
Male rats were kept for 14 days with alternating 12h periods of light and darkness. The hepatic activity of soluble phosphatidate phosphohydrolase and the concentration of serum insulin were maximum at about 2h after dark. The peak concentration of serum corticosterone occurred 2h before the dark period. It is proposed that corticosterone is partly responsible for the increased phosphohydrolase activity, and that this enables the liver to increase its capacity to synthesize triacylglycerols during the period of maximum feeding.
摘要
将雄性大鼠置于12小时光照与12小时黑暗交替的环境中饲养14天。可溶性磷脂酸磷酸水解酶的肝脏活性和血清胰岛素浓度在黑暗后约2小时达到最高。血清皮质酮的峰值浓度出现在黑暗期前2小时。有人提出，皮质酮部分导致了磷酸水解酶活性的增加，并且这使得肝脏能够在进食量最大的时期增加其合成三酰甘油的能力。
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Control of hepatic triacylglycerol synthesis. Diurnal variations in hepatic phosphatidate phosphohydrolase activity and in the concentrations of circulating insulin and corticosterone in rats.肝脏三酰甘油合成的调控。大鼠肝脏磷脂酸磷酸水解酶活性以及循环胰岛素和皮质酮浓度的昼夜变化。
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