糖皮质激素在调节肝脏中磷脂酸磷酸水解酶活性及三酰甘油合成中的作用。用葡萄糖、山梨醇、果糖、甘油和乙醇喂养大鼠的影响。
The involvement of glucocorticoids in regulating the activity of phosphatidate phosphohydrolase and the synthesis of triacylglycerols in the liver. Effects of feeding rats with glucose, sorbitol, fructose, glycerol and ethanol.
作者信息
Brindley D N, Cooling J, Burditt S L, Pritchard P H, Pawson S, Sturton R G
出版信息
Biochem J. 1979 Apr 15;180(1):195-9. doi: 10.1042/bj1800195.
Abstract
Feeding rats with sorbitol, fructose, glycerol and ethanol increases the concentration of serum corticosterone without significantly altering the concentration of insulin. This increase appears to be partly responsible for the increases in the hepatic activity of phosphatidate phosphohydrolase (compared with rats fed glucose or 0.9% NaCl) that has been reported [Sturton, Pritchard, Han & Brindley (1978) Biochem. J. 174, 667--670] and the enhanced capacity of the liver to synthesize triacylglycerols. The ethanol-induced increase in phosphohydrolase activity was largely, but not completely, prevented by adrenalectomy.
摘要
用山梨醇、果糖、甘油和乙醇喂养大鼠会增加血清皮质酮的浓度，而不会显著改变胰岛素的浓度。这种增加似乎部分导致了已报道的磷脂酸磷酸水解酶肝脏活性的增加（与喂食葡萄糖或0.9%氯化钠的大鼠相比）[斯特顿、普里查德、汉和布林德利（1978年）《生物化学杂志》174卷，667 - 670页]以及肝脏合成三酰甘油能力的增强。肾上腺切除术在很大程度上但并非完全阻止了乙醇诱导的磷酸水解酶活性增加。
相似文献
1
The involvement of glucocorticoids in regulating the activity of phosphatidate phosphohydrolase and the synthesis of triacylglycerols in the liver. Effects of feeding rats with glucose, sorbitol, fructose, glycerol and ethanol.糖皮质激素在调节肝脏中磷脂酸磷酸水解酶活性及三酰甘油合成中的作用。用葡萄糖、山梨醇、果糖、甘油和乙醇喂养大鼠的影响。
Biochem J. 1979 Apr 15;180(1):195-9. doi: 10.1042/bj1800195.
2
The involvement of phosphatidate phosphohydrolase and phospholipase A activities in the control of hepatic glycerolipid synthesis. Effects of acute feeding with glucose, fructose, sorbitol, glycerol and ethanol.磷脂酸磷酸水解酶和磷脂酶A活性在肝脏甘油脂质合成调控中的作用。葡萄糖、果糖、山梨醇、甘油和乙醇急性喂食的影响。
Biochem J. 1978 Aug 15;174(2):667-70. doi: 10.1042/bj1740667.
3
Control of hepatic triacylglycerol synthesis. Diurnal variations in hepatic phosphatidate phosphohydrolase activity and in the concentrations of circulating insulin and corticosterone in rats.肝脏三酰甘油合成的调控。大鼠肝脏磷脂酸磷酸水解酶活性以及循环胰岛素和皮质酮浓度的昼夜变化。
Biochem J. 1979 May 15;180(2):441-3. doi: 10.1042/bj1800441.
4
Mechanisms for the effects of ethanol on hepatic phosphatidate phosphohydrolase.乙醇对肝脏磷脂酸磷酸水解酶作用的机制。
Biochem J. 1978 Dec 15;176(3):885-92. doi: 10.1042/bj1760885.
5
Effects of chronic modification of dietary fat and carbohydrate on the insulin, corticosterone and metabolic responses of rats fed acutely with glucose, fructose or ethanol.长期改变膳食脂肪和碳水化合物对急性给予葡萄糖、果糖或乙醇的大鼠胰岛素、皮质酮及代谢反应的影响。
Biochem J. 1981 Nov 15;200(2):275-83. doi: 10.1042/bj2000275.
6
Effects of cyclic AMP, glucocorticoids and insulin on the activities of phosphatidate phosphohydrolase, tyrosine aminotransferase and glycerol kinase in isolated rat hepatocytes in relation to the control of triacylglycerol synthesis and gluconeogenesis.环磷酸腺苷、糖皮质激素和胰岛素对分离的大鼠肝细胞中磷脂酸磷酸水解酶、酪氨酸转氨酶和甘油激酶活性的影响及其与三酰甘油合成和糖异生控制的关系。
Biochem J. 1985 Jan 15;225(2):455-62. doi: 10.1042/bj2250455.
7
The effects of cortisol, corticotropin and thyroxine on the synthesis of glycerolipids and on the phosphatidate phosphohydrolase activity in rat liver.皮质醇、促肾上腺皮质激素和甲状腺素对大鼠肝脏甘油脂质合成及磷脂酸磷酸水解酶活性的影响。
Biochem J. 1978 Dec 15;176(3):777-84. doi: 10.1042/bj1760777.
8
Relationship between the displacement of phosphatidate phosphohydrolase from the membrane-associated compartment by chlorpromazine and the inhibition of the synthesis of triacylglycerol and phosphatidylcholine in rat hepatocytes.氯丙嗪使磷脂酸磷酸水解酶从膜相关区室移位与大鼠肝细胞中三酰甘油和磷脂酰胆碱合成受抑制之间的关系。
Biochim Biophys Acta. 1986 May 21;876(3):581-91. doi: 10.1016/0005-2760(86)90047-0.
9
Interactions of insulin, glucagon and dexamethasone in controlling the activity of glycerol phosphate acyltransferase and the activity and subcellular distribution of phosphatidate phosphohydrolase in cultured rat hepatocytes.胰岛素、胰高血糖素和地塞米松在调控培养大鼠肝细胞中磷酸甘油酰基转移酶活性以及磷脂酸磷酸水解酶活性和亚细胞分布方面的相互作用。
Biochem J. 1985 Sep 1;230(2):525-34. doi: 10.1042/bj2300525.
10
Effects of vasopressin and corticosterone on fatty acid metabolism and on the activities of glycerol phosphate acyltransferase and phosphatidate phosphohydrolase in rat hepatocytes.血管加压素和皮质酮对大鼠肝细胞脂肪酸代谢以及磷酸甘油酰基转移酶和磷脂酸磷酸水解酶活性的影响。
Biochem J. 1984 Jan 15;217(2):461-9. doi: 10.1042/bj2170461.
引用本文的文献
1
Regulation of Signaling and Metabolism by Lipin-mediated Phosphatidic Acid Phosphohydrolase Activity.脂磷酰基醇磷酸水解酶活性的信号转导和代谢调节。
Biomolecules. 2020 Sep 29;10(10):1386. doi: 10.3390/biom10101386.
2
Effect of ethanol on lipid metabolism.乙醇对脂代谢的影响。
J Hepatol. 2019 Feb;70(2):237-248. doi: 10.1016/j.jhep.2018.10.037.
3
Signal Transduction Mechanisms of Alcoholic Fatty Liver Disease: Emer ging Role of Lipin-1.酒精性脂肪肝疾病的信号转导机制：Lipin-1的新兴作用
Curr Mol Pharmacol. 2017;10(3):226-236. doi: 10.2174/1874467208666150817112109.
4
Sirtuin 1 signaling and alcoholic fatty liver disease.沉默调节蛋白1信号通路与酒精性脂肪性肝病
Hepatobiliary Surg Nutr. 2015 Apr;4(2):88-100. doi: 10.3978/j.issn.2304-3881.2014.12.06.
5
Deletion of SIRT1 from hepatocytes in mice disrupts lipin-1 signaling and aggravates alcoholic fatty liver.肝细胞中 SIRT1 的缺失会破坏脂联素-1 信号通路并加重酒精性脂肪肝。
Gastroenterology. 2014 Mar;146(3):801-11. doi: 10.1053/j.gastro.2013.11.008. Epub 2013 Nov 18.
6
Hepatic-specific lipin-1 deficiency exacerbates experimental alcohol-induced steatohepatitis in mice.肝特异性脂肪酶-1 缺乏症加剧了实验性酒精诱导的小鼠脂肪性肝炎。
Hepatology. 2013 Dec;58(6):1953-63. doi: 10.1002/hep.26589. Epub 2013 Oct 17.
7
Regulation of hepatic lipin-1 by ethanol: role of AMP-activated protein kinase/sterol regulatory element-binding protein 1 signaling in mice.乙醇对肝脂酶-1的调节：在小鼠中 AMP 激活的蛋白激酶/固醇调节元件结合蛋白 1 信号通路的作用。
Hepatology. 2012 Feb;55(2):437-46. doi: 10.1002/hep.24708. Epub 2011 Dec 29.
8
Involvement of adiponectin-SIRT1-AMPK signaling in the protective action of rosiglitazone against alcoholic fatty liver in mice.脂联素-SIRT1-AMPK 信号通路在罗格列酮防治酒精性脂肪肝中的作用。
Am J Physiol Gastrointest Liver Physiol. 2010 Mar;298(3):G364-74. doi: 10.1152/ajpgi.00456.2009. Epub 2009 Dec 10.
9
Regulation of lipin-1 gene expression by glucocorticoids during adipogenesis.脂肪生成过程中糖皮质激素对lipin-1基因表达的调控
J Lipid Res. 2008 Jul;49(7):1519-28. doi: 10.1194/jlr.M800061-JLR200. Epub 2008 Mar 24.
10
Glucocorticoids and cyclic AMP selectively increase hepatic lipin-1 expression, and insulin acts antagonistically.糖皮质激素和环磷酸腺苷选择性增加肝脏中脂联素-1的表达，而胰岛素则起拮抗作用。
J Lipid Res. 2008 May;49(5):1056-67. doi: 10.1194/jlr.M800013-JLR200. Epub 2008 Feb 2.
本文引用的文献
1
A simple fluorimetric method for the estimation of free 11-hydroxycorticoids in human plasma.一种用于测定人血浆中游离11-羟基皮质类固醇的简易荧光法。
J Clin Pathol. 1962 Jul;15(4):374-9. doi: 10.1136/jcp.15.4.374.
2
HYPERGLYCERIDEMIA INDUCED BY GLYCEROL FEEDING.甘油喂养诱导的高甘油三酯血症。
Life Sci (1962). 1964 Sep;3:1021-3. doi: 10.1016/0024-3205(64)90114-6.
3
A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid.用于比色法测定脱氧核糖核酸的二苯胺反应的条件及机制研究。
Biochem J. 1956 Feb;62(2):315-23. doi: 10.1042/bj0620315.
4
Effect of adrenalcortical hormones on release of triglycerides and glucose by liver.肾上腺皮质激素对肝脏释放甘油三酯和葡萄糖的影响。
Am J Physiol. 1967 Jun;212(6):1236-46. doi: 10.1152/ajplegacy.1967.212.6.1236.
5
An enzymatic explanation for dietary induced alterations in hepatic glycerolipid metabolism.饮食诱导的肝脏甘油脂质代谢改变的酶学解释。
Biochim Biophys Acta. 1974 Apr 26;348(1):179-88. doi: 10.1016/0005-2760(74)90104-0.
6
7
A study of some enzymes of glycerolipid biosynthesis in rat liver after subtotal hepatectomy.大鼠肝大部切除术后甘油脂质生物合成的某些酶的研究。
Biochem J. 1973 May;134(1):103-12. doi: 10.1042/bj1340103.
8
Some studies of the protein-binding of steroids and their application to the routine micro and ultramicro measurement of various steroids in body fluids by competitive protein-binding radioassay.一些关于类固醇蛋白质结合的研究及其在通过竞争性蛋白质结合放射分析法对体液中各种类固醇进行常规微量和超微量测量中的应用。
J Clin Endocrinol Metab. 1967 Jul;27(7):973-90. doi: 10.1210/jcem-27-7-973.
9
Determination of dehydroepiandrosterone and dehydroepiandrosterone sulphate in human plasma using electron capture detection of 4-androstene-3,6,17-trione after gas-liquid chromatography.
J Endocrinol. 1972 Jun;53(3):461-74. doi: 10.1677/joe.0.0530461.
10
Abnormal stress reactions after feeding diets rich in (very) long-chain fatty acids: high levels of corticosterone and testosterone.
Mol Cell Endocrinol. 1978 Oct;12(1):1-8. doi: 10.1016/0303-7207(78)90096-5.
Zotero 插件