Luo G Y, He Y, Tu L B
Department of Physiology, Jiangxi University, Nanchang, China.
Zhongguo Yao Li Xue Bao. 1990 Sep;11(5):457-9.
Clonidine 2 mg/kg ig inhibited the rat gastric ulcers induced by pyloric ligation, stress and indomethacin by 71%, 77% and 82%, respectively. Clonidine 2 mg/kg ig tended to accelerate the healing of gastric ulcer induced by acetic acid, and the healing rate was 61%. Clonidine decreased the secretion of gastric acid and pepsin, and increased the release of gastric barrier mucus. These actions may contribute to its protective effect against ulceration.
可乐定2毫克/千克腹腔注射分别使幽门结扎、应激和消炎痛诱导的大鼠胃溃疡的发生率降低了71%、77%和82%。可乐定2毫克/千克腹腔注射有加速乙酸诱导的胃溃疡愈合的趋势，愈合率为61%。可乐定可减少胃酸和胃蛋白酶的分泌，并增加胃黏膜屏障黏液的释放。这些作用可能有助于其对溃疡的保护作用。
