Zhang S R, Xue L, Yu Y W
Yao Xue Xue Bao. 1989;24(8):562-7.
Pyrrole aldehydephenyl semicarbazone was shown to be an effective anti-ulcer agent in five experimental models in rats, namely, the indomethacin-induced, acetic acid-induced, pyloric ligation-induced and 0.6 mol HCl, absolute alcohol-induced ulcers, at doses of 40-100 mg/kg. Its anti-ulcer activity and characteristics are similar to those of furazolidone. Its oral acute toxicity in mouse is much lower than furazolidone. This compound exhibited mild inhibitory effects on gastric pepsin secretion, caused increases in hexosamine level and decreases of DNA content in gastric juice. It showed no influence on gastric acid secretion and was considered to have "cytoprotective action" on the gastric mucosa. However, this compound was found to be ineffective against the stress-restraint gastric ulcer model.
吡咯醛苯氨基脲在大鼠的五种实验模型中被证明是一种有效的抗溃疡剂，即吲哚美辛诱导型、乙酸诱导型、幽门结扎诱导型以及0.6摩尔盐酸和无水乙醇诱导型溃疡，给药剂量为40 - 100毫克/千克。其抗溃疡活性和特性与呋喃唑酮相似。它对小鼠的口服急性毒性远低于呋喃唑酮。该化合物对胃蛋白酶分泌有轻微抑制作用，使胃液中氨基己糖水平升高，DNA含量降低。它对胃酸分泌没有影响，被认为对胃黏膜有“细胞保护作用”。然而，发现该化合物对应激 - 束缚型胃溃疡模型无效。
