从罗汉松中提取的致癌转录因子 AP-1 抑制剂。
Inhibitors of the oncogenic transcription factor AP-1 from Podocarpus latifolius.
机构信息
Molecular Targets Laboratory, Molecular Discovery Program, National Cancer Institute, Frederick, Maryland 21702, United States.
出版信息
J Nat Prod. 2011 Mar 25;74(3):374-7. doi: 10.1021/np100736y. Epub 2011 Feb 9.
Abstract
An activator protein-1 (AP-1) based bioassay-guided phytochemical investigation on Podocarpus latifolius led to the isolation of three new sempervirol-type diterpenes, cycloinumakiol (1), inumakal (2), and inumakoic acid (3), along with three known norditerpenes (4-6). Compounds 4 and 6 were responsible for the observed bioactivity.
摘要
基于激活蛋白-1 (AP-1) 的生物测定法对罗汉松进行的植物化学研究导致分离出三种新型的半萜烯型二萜，即环诺玛基醇（1）、依诺马卡醇（2）和依诺马卡酸（3），以及三种已知的北美二萜（4-6）。化合物 4 和 6 负责观察到的生物活性。
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