Barrett Emily S, Groth Susan W, Preston Emma V, Kinkade Carolyn, James-Todd Tamarra
Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, NJ 08854, USA.
Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, NJ 08854, USA.
Curr Epidemiol Rep. 2021 Sep;8(3):130-142. doi: 10.1007/s40471-021-00272-7. Epub 2021 Aug 9.
Pregnancy can be seen as a "stress test" with complications predicting later-life cardiovascular disease risk. Here, we review the growing epidemiological literature evaluating environmental endocrine-disrupting chemical (EDC) exposure in pregnancy in relation to two important cardiovascular disease risk factors, hypertensive disorders of pregnancy and maternal obesity.
Overall, evidence of EDC-maternal cardiometabolic associations was mixed. The most consistent associations were observed for phenols and maternal obesity, as well as for perfluoroalkyl substances (PFASs) with hypertensive disorders. Research on polybrominated flame retardants and maternal cardiometabolic outcomes is limited, but suggestive.
Although numerous studies evaluated pregnancy outcomes, few evaluated the postpartum period or assessed chemical mixtures. Overall, there is a need to better understand whether pregnancy exposure to these chemicals could contribute to adverse cardiometabolic health outcomes in women, particularly given that cardiovascular disease is the leading cause of death in women.
妊娠可被视为一种“压力测试”，其并发症可预测日后患心血管疾病的风险。在此，我们综述了越来越多的流行病学文献，这些文献评估了孕期环境内分泌干扰化学物（EDC）暴露与两个重要的心血管疾病风险因素——妊娠高血压疾病和孕妇肥胖之间的关系。
总体而言，关于EDC与母亲心脏代谢关联的证据喜忧参半。酚类与孕妇肥胖以及全氟烷基物质（PFASs）与妊娠高血压疾病之间的关联最为一致。关于多溴联苯阻燃剂与母亲心脏代谢结局的研究有限，但具有一定提示性。
尽管众多研究评估了妊娠结局，但很少有研究评估产后时期或评估化学混合物。总体而言，有必要更好地了解孕期接触这些化学物质是否会导致女性出现不良的心脏代谢健康结局，特别是考虑到心血管疾病是女性的主要死因。
