Roberts C M, Butland R J, Saunders C, Greenland J H, Hodson M E
National Heart and Lung Institute, London, England.
Acta Univ Carol Med (Praha). 1990;36(1-4):86-8.
In vitro studies have suggested a potential role for calcium channel blockers in manipulating the basic ionic defect of cystic fibrosis. In 17 adult patients with cystic fibrosis nicardipine was administered either intravenously or topically using iontophoresis or occlusive dressings. Sweat tests were performed before and after drug administration and examined using two way analysis of variance. No statistically significant difference was observed. We conclude that nicardipine used in vivo does not exert the easily demonstrable effect on the chloride ion defect that has been observed with other agents in vitro.
体外研究表明，钙通道阻滞剂在控制囊性纤维化的基本离子缺陷方面可能发挥作用。对17名成年囊性纤维化患者，通过静脉给药或采用离子电渗疗法或封闭敷料进行局部给药，使用尼卡地平。在给药前后进行汗液测试，并采用双向方差分析进行检查。未观察到统计学上的显著差异。我们得出结论，体内使用的尼卡地平对氯离子缺陷并未产生如其他药物在体外所观察到的那种易于证实的效果。
