当前对肠道微生物群的认识和感染的发病机制。
Current concepts of the intestinal microbiota and the pathogenesis of infection.
机构信息
Department of Immunology and Infectious Diseases, Harvard School of Public Health, 665 Huntington Avenue, SPH 1 909, Boston, MA, 02115, USA,
出版信息
Curr Infect Dis Rep. 2011 Feb;13(1):28-34. doi: 10.1007/s11908-010-0147-7.
Abstract
The human gastrointestinal tract is populated by a vast and diverse community of microbes. This gut microbiota participates in host metabolism, protects from invading microbes, and facilitates immune system development and function. In this review, we consider the contributions of intestinal microbes to the pathogenesis of infectious diseases. Key concepts of colonization resistance, host-commensal microbe interaction in immunity, antibiotics and gut bacterial communities, viral-gut bacterial interactions, and evolving methods for studying commensal microbes are explored.
摘要
人体胃肠道中栖息着庞大而多样的微生物群落。这些肠道微生物参与宿主代谢，抵御入侵微生物，并促进免疫系统的发育和功能。在这篇综述中，我们考虑了肠道微生物对传染病发病机制的影响。探讨了定植抗性、宿主共生微生物在免疫中的相互作用、抗生素和肠道细菌群落、病毒-肠道细菌相互作用以及研究共生微生物的不断发展的方法等关键概念。
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本文引用的文献
1
Viruses in the faecal microbiota of monozygotic twins and their mothers.双歧杆菌在同卵双胞胎及其母亲粪便微生物群中的病毒。
Nature. 2010 Jul 15;466(7304):334-8. doi: 10.1038/nature09199.
2
Toward defining the autoimmune microbiome for type 1 diabetes.针对 1 型糖尿病的自身免疫微生物组进行定义。
ISME J. 2011 Jan;5(1):82-91. doi: 10.1038/ismej.2010.92. Epub 2010 Jul 8.
3
Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestine.病毒加易感性基因相互作用决定肠道克罗恩病基因 Atg16L1 表型。
Cell. 2010 Jun 25;141(7):1135-45. doi: 10.1016/j.cell.2010.05.009.
4
A polysaccharide from the human commensal Bacteroides fragilis protects against CNS demyelinating disease.人体共生拟杆菌脆弱亚种的一种多糖可预防中枢神经系统脱髓鞘疾病。
Mucosal Immunol. 2010 Sep;3(5):487-95. doi: 10.1038/mi.2010.29. Epub 2010 Jun 9.
5
Inadequate clearance of translocated bacterial products in HIV-infected humanized mice.HIV 感染的人源化小鼠中转位细菌产物清除不足。
PLoS Pathog. 2010 Apr 29;6(4):e1000867. doi: 10.1371/journal.ppat.1000867.
6
Exposure to HIV-1 directly impairs mucosal epithelial barrier integrity allowing microbial translocation.HIV-1 的暴露会直接损害黏膜上皮屏障的完整性，从而允许微生物易位。
PLoS Pathog. 2010 Apr 8;6(4):e1000852. doi: 10.1371/journal.ppat.1000852.
7
QIIME allows analysis of high-throughput community sequencing data.QIIME可用于分析高通量群落测序数据。
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