Department of Surgical Oncology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, China.
J Surg Oncol. 2011 Jun 1;103(7):700-3. doi: 10.1002/jso.21878. Epub 2011 Feb 9.
Signet ring cell carcinoma (SRC) of the stomach is a histological type based on microscopic characteristics, and its clinicopathologic characteristics and prognosis are still controversial.
A retrospective analysis was under taken for 2,315 patients with gastric cancer who had undergone gastrectomy from 1980 to 2004. Among them, 211 patients had SRC and were compared with 2,104 patients with non-signet ring cell carcinoma (NSRC).
Significant differences were noted in age, gender, and depth of tumor invasion between patients with SRC and NSRC of early gastric carcinoma. There were statistically significant differences in age, gender, macroscopic appearance, tumor size, depth of tumor invasion, peritoneal dissemination, and curability between patients with SRC and NSRC of advanced gastric carcinoma. In early gastric carcinoma, patients with SRC had a significantly better survival rate than those with NSRC, and the signet ring cell histology was an independent predictive factor. In advanced gastric carcinoma, there was no significant difference of survival rate between SRC and NSRC, and the signet ring cell histology was not an independent predictive factor.
SRC is a distinct type of gastric carcinoma in terms of clinicopathologic characteristics and prognosis.
胃的印戒细胞癌（SRC）是基于显微镜下特征的组织学类型，其临床病理特征和预后仍存在争议。
对 1980 年至 2004 年间接受胃切除术的 2315 例胃癌患者进行回顾性分析。其中 211 例为 SRC，并与 2104 例非印戒细胞癌（NSRC）患者进行比较。
早期胃癌中 SRC 患者与 NSRC 患者在年龄、性别和肿瘤浸润深度方面存在显著差异。在晚期胃癌中，SRC 患者与 NSRC 患者在年龄、性别、大体形态、肿瘤大小、肿瘤浸润深度、腹膜播散和可治愈性方面存在统计学差异。在早期胃癌中，SRC 患者的生存率明显优于 NSRC 患者，印戒细胞组织学是独立的预测因素。在晚期胃癌中，SRC 和 NSRC 的生存率无显著差异，印戒细胞组织学不是独立的预测因素。
SRC 在临床病理特征和预后方面是一种独特的胃癌类型。
