Li Xiaoxuan, Luan Xinchi, Yu Wenjuan, Wang Shibo, Li Xiangxue, Zhang Lihua, Zhang Siyi, Song Jialin, Guo Jing, Wang Shasha, Qiu Wensheng, Lv Jing
Department of Oncology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Department of Pathology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Cancer Sci. 2025 Aug;116(8):2064-2074. doi: 10.1111/cas.70112. Epub 2025 Jun 11.
Gastric cancer is rare in pediatric populations, with gastric signet ring cell carcinoma (GSRCC) being an exceptionally infrequent subtype. We report a case of GSRCC in a 10-year-old Chinese boy with no family history of cancer. The diagnosis was established via gastroscopy, endoscopic ultrasound, and imaging examinations. Early detection allowed a successful distal gastrectomy with D2 lymph node dissection. Postoperative whole-exome sequencing (WES) revealed no clinically significant mutations but identified some somatic alterations. Notably, gastric biopsy pathology demonstrated strong positivity for Helicobacter pylori (H. pylori) infection. Additionally, we comprehensively reviewed the existing pediatric GSRCC cases, suggesting the potential role of H. pylori infection in the pathogenesis of pediatric gastric cancer.
胃癌在儿童群体中较为罕见，胃印戒细胞癌（GSRCC）是一种极其罕见的亚型。我们报告了一例10岁中国男孩的GSRCC病例，该男孩无癌症家族史。通过胃镜检查、内镜超声检查和影像学检查确诊。早期发现使得成功进行了远端胃切除术及D2淋巴结清扫术。术后全外显子测序（WES）未发现具有临床意义的突变，但识别出了一些体细胞改变。值得注意的是，胃活检病理显示幽门螺杆菌（H. pylori）感染呈强阳性。此外，我们全面回顾了现有的儿童GSRCC病例，提示H. pylori感染在儿童胃癌发病机制中的潜在作用。
