Channer J L, Mackenzie E F
Department of Cytology, Southmead General Hospital, Westbury-on-Trym, Bristol.
Cytopathology. 1990;1(1):13-7. doi: 10.1111/j.1365-2303.1990.tb00321.x.
This study examines the effect of a change in screening policy on the detection rate of severe dyskaryosis. During 1987 a total of 423 cases of severe dyskaryosis were identified by the Avon Screening Programme. Eleven per cent of these abnormal smears were repeat smears taken without clinical indication within the recommended 5 year recall period (interval smears). In a comparable control group of negative smears 31% were interval smears. Twenty-five per cent of the dyskaryotic interval smears (3% of the total severely dyskaryotic smears) were taken within 3 years of the previous negative smear, compared with 50% of the control group. By discouraging opportunistic smears within 5 years of the previous smear, the laboratory workload could be reduced by 30%, or within 3 years of the previous smear by 15%. There is, however, a risk of 11% and 3% respectively of missing a significant lesion (severe dyskaryosis).
本研究考察了筛查政策的变化对重度核异质检出率的影响。1987年，雅芳筛查项目共识别出423例重度核异质病例。这些异常涂片中有11%是在推荐的5年召回期内无临床指征进行的重复涂片（间隔涂片）。在一个涂片结果为阴性的可比对照组中，31%是间隔涂片。25%的核异质间隔涂片（占所有重度核异质涂片的3%）是在前一次涂片结果为阴性后的3年内进行的，而对照组这一比例为50%。通过不鼓励在前一次涂片后的5年内进行机会性涂片，实验室工作量可减少30%，在前一次涂片后的3年内进行则可减少15%。然而，分别有11%和3%的风险会漏诊显著病变（重度核异质）。
