Durno Alexandra S, Webb Jinelle A, Gauthier Meredith J, Bienzle Dorothee
Mississauga-Oakville Veterinary Emergency Hospital and Referral Group, Oakville, ON, Canada.
J Am Anim Hosp Assoc. 2011 Mar-Apr;47(2):122-8. doi: 10.5326/JAAHA-MS-5614. Epub 2011 Feb 10.
Two dogs presented with suspected renal disease and polycythemia. Abdominal ultrasound examinations performed on both dogs revealed coalescing masses causing bilateral renomegaly. Serum erythropoietin (EPO) concentrations were physiologically inappropriate. Postmortem examinations revealed renal T-cell lymphoma in both dogs. One of the two dogs also had involvement of the liver and mesentery. EPO-immunohistochemistry on tissue samples demonstrated positive staining in tumor cells and occasional normal renal cells. This report illustrates that paraneoplastic EPO production may induce polycythemia. The pattern of EPO-immunohistochemistry staining suggested that the mechanism of production was due to tumor production of EPO and local hypoxia-induced EPO production from compression of normal renal cells and vasculature.
两只犬出现疑似肾病和红细胞增多症。对这两只犬进行的腹部超声检查显示，融合性肿块导致双侧肾肿大。血清促红细胞生成素（EPO）浓度在生理上不适当。尸检显示两只犬均患有肾T细胞淋巴瘤。两只犬中的一只还伴有肝脏和肠系膜受累。对组织样本进行的EPO免疫组化显示肿瘤细胞和偶尔的正常肾细胞呈阳性染色。本报告表明，肿瘤旁分泌EPO可能诱导红细胞增多症。EPO免疫组化染色模式提示，其产生机制是由于肿瘤产生EPO以及正常肾细胞和血管受压导致局部缺氧诱导EPO产生。
