Michael Aleisha E, Grimes Janet A, Volstad Nicola J, Osekavage Katie E, Koenig Amie
Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA, USA.
Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA, USA.
Top Companion Anim Med. 2019 Sep;36:9-11. doi: 10.1053/j.tcam.2019.05.002. Epub 2019 May 15.
A 7-year-old mixed breed dog was evaluated for erythrocytosis with an initial hematocrit of 82.3%. Abdominal ultrasound revealed a 6 cm mass on the cranial pole of the right kidney. Daily therapeutic phlebotomies were performed, reducing the hematocrit to 54%. The dog underwent a right nephroureterectomy, recovered without complications, and was discharged 3 days after surgery. Histopathologic evaluation revealed a completely excised grade II soft tissue sarcoma. The preoperative erythropoietin level was 7.00 mU/mL (RI 1.90-22.90 mU/mL) and the 3-day postoperative erythropoietin level was 0.99 mU/mL, supporting a diagnosis of inappropriate secondary erythrocytosis due to the renal tumor. Secondary erythrocytosis resulting from renal soft tissue sarcoma is rare. Confirmatory testing with erythropoietin levels can assist in the diagnosis of secondary erythrocytosis. Erythropoietin levels that are normal or increased in the face of erythrocytosis indicate a source of inappropriate erythropoietin production.
一只7岁的混血犬因红细胞增多症接受评估，初始血细胞比容为82.3%。腹部超声显示右肾头极有一个6厘米的肿块。每天进行治疗性放血，将血细胞比容降至54%。这只狗接受了右肾输尿管切除术，术后恢复顺利，无并发症，并在术后3天出院。组织病理学评估显示为完全切除的II级软组织肉瘤。术前促红细胞生成素水平为7.00 mU/mL（参考区间1.90 - 22.90 mU/mL），术后3天促红细胞生成素水平为0.99 mU/mL，支持因肾肿瘤导致的不适当继发性红细胞增多症的诊断。肾软组织肉瘤导致的继发性红细胞增多症很罕见。通过促红细胞生成素水平进行确诊检测有助于继发性红细胞增多症的诊断。在红细胞增多症情况下，促红细胞生成素水平正常或升高表明存在不适当的促红细胞生成素产生来源。
