Troia Roberta, Agnoli Chiara, Fracassi Federico, Bettini Giuliano, Sfacteria Alessandra, Pisoni Luciano, Dondi Francesco
Department of Veterinary Medical Sciences, Alma Mater Studiorum-University of Bologna, Italy.
Department of Veterinary Sciences, University of Messina, Italy.
Open Vet J. 2017;7(4):294-299. doi: 10.4314/ovj.v7i4.1. Epub 2017 Oct 19.
This report documents a case of secondary inappropriate erythrocytosis in a cat with renal cell adenocarcinoma, its stabilization through manual erythrocytapheresis, and the EPO-immunostaining on the affected kidney. An 11-year-old cat was presented with lethargy, weight loss and polyuria/polydipsia. An abdominal mass was detected upon physical examination. Clinicopathological work-up revealed marked erythrocytosis (HCT value 64.8%), renal azotemia and decreased urine specific gravity (USG). An abdominal ultrasound was performed, localizing the mass in the right kidney. Serum erythropoietin (EPO) was above the reference interval (RI), and the cytology of the mass was indicative of renal carcinoma. Manual erythrocytapheresis was performed in order to stabilize the patient before surgery, improving the cat's clinical and clinicopathological condition. After nephrectomy, EPO and creatinine concentrations returned within the RI, while the USG markedly increased. Histopathology confirmed the diagnosis of renal adenocarcinoma. Immunohistochemistry with anti-EPO antibody revealed diffuse and strong cytoplasmatic positivity in tumor cells.
本报告记录了一例患有肾细胞腺癌的猫继发性不适当红细胞增多症病例，通过手工红细胞单采术使其病情稳定，并对患肾进行了促红细胞生成素免疫染色。一只11岁的猫出现嗜睡、体重减轻和多尿/多饮症状。体格检查发现腹部有肿块。临床病理检查显示明显的红细胞增多症（血细胞比容值64.8%）、肾性氮质血症和尿比重降低（USG）。进行了腹部超声检查，将肿块定位在右肾。血清促红细胞生成素（EPO）高于参考区间（RI），肿块的细胞学检查提示为肾癌。为在手术前稳定患者病情，进行了手工红细胞单采术，改善了猫的临床和临床病理状况。肾切除术后，EPO和肌酐浓度恢复到RI范围内，而USG显著升高。组织病理学确诊为肾腺癌。用抗EPO抗体进行免疫组织化学检查显示肿瘤细胞胞质弥漫性强阳性。
