Chronic Pancreatic Study Group, Department of Gastroenterology, Changhai Hospital, The Second Military Medical University, Shanghai, China.
Pancreatology. 2011;11(1):16-23. doi: 10.1159/000322982. Epub 2011 Feb 10.
It is suggested that patients with chronic pancreatitis (CP) have a markedly increased risk of pancreatic cancer compared with the general population. This study was designed to determine the rate of pancreatic cancer in CP patients in China.
This was a semiprospective, single-center study including 420 consecutive CP patients (285 males and 135 females, median age at onset 39.5 years), with the median follow-up time being 102.3 months (range 24-419 months). We calculated the standardized incidence ratio (SIR) based on the pancreatic cancer incidence in the general population of China.
Four cases of pancreatic cancer (0.9% of patients) were observed in 3,591 patient-years (expected number of cases 0.15; SIR 27.2, 95% CI 7.4-69.6). Similar results were seen in alcoholics and non-alcoholics, and in smokers and non-smokers. When patients lost to follow-up were considered to be followed up until the end point without having developed pancreatic cancer (4,280 patient-years), SIR was 22.8 (CI 6.2-58.4). Based on the Cox model, with inserting factors being sex, age at the time of CP clinical onset, type of pancreatitis, and presence or absence of diabetes, calcification, alcohol use and smoking status, only age was found to correlate positively with the occurrence of pancreatic cancer (>50 years, hazard ratio, 1.8 ± 0.5; p = 0.044).
The risk of pancreatic cancer is markedly increased in CP patients in China compared with the general population, especially in older patients. and IAP.
有研究表明，与普通人群相比，慢性胰腺炎（CP）患者发生胰腺癌的风险明显增加。本研究旨在确定中国 CP 患者中胰腺癌的发生率。
这是一项半前瞻性、单中心研究，纳入了 420 例连续 CP 患者（285 例男性，135 例女性；发病时的中位年龄为 39.5 岁），中位随访时间为 102.3 个月（24-419 个月）。我们根据中国普通人群的胰腺癌发病率计算标准化发病比（SIR）。
在 3591 患者-年中观察到 4 例胰腺癌（0.9%的患者）（预期病例数为 0.15；SIR 为 27.2，95%CI 为 7.4-69.6）。在酒精性和非酒精性 CP 患者、吸烟者和非吸烟者中均观察到类似的结果。当将失访患者视为随访至终点而未发生胰腺癌（4280 患者-年）时，SIR 为 22.8（CI 为 6.2-58.4）。基于 Cox 模型，插入性别、CP 发病时的年龄、胰腺炎类型、是否存在糖尿病、钙化、饮酒和吸烟状态等因素后，仅年龄与胰腺癌的发生呈正相关（>50 岁，风险比 1.8±0.5；p=0.044）。
与普通人群相比，中国 CP 患者发生胰腺癌的风险明显增加，尤其是年龄较大的患者。
