Rupniak H T, Paul D
Biochim Biophys Acta. 1978 Sep 21;543(1):10-5. doi: 10.1016/0304-4165(78)90449-x.
Various hormonal and non-hormonal agents were tested for their ability to induce ornithine decarboxylase (EC 4.1.1.17) in primary cultures of fetal rat liver cells that retain many of the differentiated functions of hepatocytes. The only agents to induce ornithine decarboxylase in this cell type were fetal calf serum, prostaglandin E1 and cyclic AMP derivatives. Also, the amino acid arginine would induce ornithine decarboxylase in this cell type following arginine starvation for 24 h. These observations are in contrast to the wide range of hormones, e.g. insulin, hydrocortisone, glucagon and growth hormone, than can induce ornithine decarboxylase in vivo in the adult rat liver but which are all without effect on fetal rat liver cells.
在保留肝细胞许多分化功能的胎鼠肝细胞原代培养物中，测试了各种激素和非激素制剂诱导鸟氨酸脱羧酶（EC 4.1.1.17）的能力。在这种细胞类型中，唯一能诱导鸟氨酸脱羧酶的制剂是胎牛血清、前列腺素E1和环磷酸腺苷衍生物。此外，在精氨酸饥饿24小时后，氨基酸精氨酸会在这种细胞类型中诱导鸟氨酸脱羧酶。这些观察结果与多种激素形成对比，例如胰岛素、氢化可的松、胰高血糖素和生长激素，它们在成年大鼠肝脏中可在体内诱导鸟氨酸脱羧酶，但对胎鼠肝细胞均无作用。
