Centre for Infectious Disease Control, National Institute for Public Health and the Environment, PO Box 1, 3720 BA Bilthoven, The Netherlands.
BMC Infect Dis. 2011 Feb 11;11:44. doi: 10.1186/1471-2334-11-44.
Q fever has become a major public health problem in The Netherlands. Infection with Coxiella burnetii (Q fever) during pregnancy has resulted in adverse pregnancy outcome in the majority of reported cases. Therefore, we aimed to quantify this risk by examining the earliest periods corresponding to the epidemic in The Netherlands.
Serum samples that had been collected from the area of highest incidence by an existing national prenatal screening programme and data from the Netherlands Perinatal Registry (PRN) on diagnosis and outcome were used. We performed indirect immunofluorescence assay to detect the presence of IgM and IgG antibodies against C. burnetii in the samples. The serological results were analyzed to determine statistical association with recorded pregnancy outcome.
Evaluation of serological results for 1174 women in the PRN indicated that the presence of IgM and IgG antibodies against phase II of C. burnetii was not significantly associated with preterm delivery, low birth weight, or several other outcome measures.
The present population-based study showed no evidence of adverse pregnancy outcome among women who had antibodies to C. burnetii during early pregnancy.
Q 热已成为荷兰的一个主要公共卫生问题。在大多数报告的病例中，孕妇感染柯克斯体（Q 热）导致妊娠结局不良。因此，我们旨在通过检查与荷兰流行相对应的最早时期来量化这种风险。
使用了现有的全国产前筛查计划在发病率最高的地区采集的血清样本和荷兰围产期登记处（PRN）关于诊断和结局的数据。我们使用间接免疫荧光测定法检测样品中针对 C. burnetii 的 IgM 和 IgG 抗体的存在。对血清学结果进行分析以确定与记录的妊娠结局的统计学关联。
对 PRN 中 1174 名妇女的血清学结果进行评估表明，针对 C. burnetii 相 II 的 IgM 和 IgG 抗体的存在与早产、低出生体重或其他几个结局指标无显著关联。
本基于人群的研究表明，在妊娠早期具有 C. burnetii 抗体的妇女中，没有不良妊娠结局的证据。
