Ullah Qudrat, Jamil Tariq, Saqib Muhammad, Iqbal Mudassar, Neubauer Heinrich
Faculty of Veterinary and Animal Sciences, The University of Agriculture, Dera Ismail Khan 29111, Pakistan.
Institute of Bacterial Infections and Zoonoses, Friedrich-Loeffler-Institut, 07743 Jena, Germany.
Microorganisms. 2022 Jul 28;10(8):1530. doi: 10.3390/microorganisms10081530.
Q fever remains a neglected zoonosis in many developing countries including Pakistan. The causing agent is resistant to environmental factors (such as drying, heat and many disinfectants), resulting in a long-lasting infection risk for both human and animals. As the infection is usually asymptomatic, it mostly remains undiagnosed in animals until and unless adverse pregnancy outcomes occur in a herd. In humans, the infection leads to severe endocarditis and vascular infection in chronic cases. Limited data are available on molecular epidemiology and evolution of this pathogen, especially in ruminants. Genomic studies will help speculating outbreak relationships in this scenario. Likewise, pathogenesis of needs to be explored by molecular studies. Awareness programs and ensuring pasteurization of the dairy milk before human consumption would help preventing Q fever zoonosis.
在包括巴基斯坦在内的许多发展中国家，Q热仍然是一种被忽视的人畜共患病。其致病因子对环境因素（如干燥、高温和许多消毒剂）具有抗性，导致人类和动物都面临长期的感染风险。由于感染通常无症状，在畜群中，除非出现不良妊娠结局，否则感染大多在动物身上未被诊断出来。在人类中，慢性病例的感染会导致严重的心内膜炎和血管感染。关于这种病原体的分子流行病学和进化，尤其是在反刍动物中的数据有限。基因组研究将有助于推测这种情况下的疫情关系。同样，需要通过分子研究来探索其发病机制。提高认识的项目以及确保在人类食用前对牛奶进行巴氏杀菌将有助于预防Q热人畜共患病。
