Karolinska Institutet, NVS, Section of Applied Neuroendocrinology, Mandometer and Mandolean Clinics, Novum, S-14104 Huddinge, Sweden.
Physiol Behav. 2011 Jun 1;103(3-4):290-4. doi: 10.1016/j.physbeh.2011.01.025. Epub 2011 Feb 18.
IOAKIMIDIS I, M. ZANDIAN, F. ULBL, C. BERGH, M LEON, AND P. SÖDERSTEN. How eating affects mood. PHYSIOL BEHAV 2011 (000) 000-000. We hypothesize that the changes in mood that are associated with eating disorders are caused by a change in eating behavior. When food is in short supply, the rhythm of the neural network for eating, including orbitofrontal cortex and brainstem, slows down and we suggest that this type of neural activity activates a partially overlapping neural network for mood, including dorsal raphe serotonin projections to the orbitofrontal and prefrontal cortex. As a consequence, people who restrict the amount of food that they consume, either by choice or by their limited access to food, become preoccupied with food and food-related behavior. Most eating disorders emerge from a history of dietary restriction and we suggest that disordered eating consequent upon food restriction produces the altered mental state of patients with eating disorders. Based on the present hypothesis, eating disorders are not the result of a primary mental disorder. Rather, this notion suggests that the patients should be treated by learning to eat an appropriate amount of food at an appropriate rate.
IOAKIMIDIS I、M. ZANDIAN、F. ULBL、C. BERGH、M LEON 和 P. SÖDERSTEN。进食如何影响情绪。生理学与行为 2011（000）000-000。我们假设与饮食失调相关的情绪变化是由进食行为的变化引起的。当食物供应短缺时，包括眶额皮质和脑干在内的进食神经网络的节律会减慢，我们认为这种类型的神经活动会激活部分重叠的情绪神经网络，包括中缝背核 5-羟色胺投射到眶额和前额皮质。因此，那些限制食物摄入量的人，无论是出于选择还是因为食物有限，都会专注于食物和与食物相关的行为。大多数饮食失调症都源于节食史，我们认为，由于节食而导致的饮食失调会导致饮食失调症患者出现改变的精神状态。基于目前的假设，饮食失调症不是原发性精神障碍的结果。相反，这一观点表明，应该通过学习以适当的速度进食适量的食物来治疗患者。
