Laboratory of Pharmacology, Department of Oncology Biology and Genetics, University of Genova, 16132 Genova, Italy.
J Neuroimmunol. 2011 May;234(1-2):115-23. doi: 10.1016/j.jneuroim.2011.01.006. Epub 2011 Feb 11.
CXCR4 and CXCR7 chemokine receptors, and their ligands CXCL11 and CXCL12, have been often involved in tumor cell proliferation and survival. We report the expression pattern of these ligand/receptor pairs in 22 human meningiomas. High CXCR7 and CXCL12 expression was associated with high-proliferative tumors. CXCR7 levels were correlated to the content of both ligands, suggesting a possible autocrine regulation. CXCR4 and CXCL12 were homogeneously expressed within tumor cells, while CXCR7 was mainly detected in tumor endothelial cells and CXCL11 in pericytes. Our results highlight the preferential CXCR7 and CXCL12 expression within more aggressive tumors and the possible role of CXCR7 in meningioma vascularization.
趋化因子受体 CXCR4 和 CXCR7 及其配体 CXCL11 和 CXCL12 常参与肿瘤细胞的增殖和存活。我们报告了这 22 个人脑膜瘤中这些配体/受体对的表达模式。高表达 CXCR7 和 CXCL12 与高增殖性肿瘤相关。CXCR7 水平与两种配体的含量相关，提示可能存在自分泌调节。CXCR4 和 CXCL12 在肿瘤细胞内均匀表达，而 CXCR7 主要在肿瘤内皮细胞中检测到，CXCL11 在周细胞中检测到。我们的结果强调了更具侵袭性肿瘤中 CXCR7 和 CXCL12 的优先表达，以及 CXCR7 在脑膜瘤血管生成中的可能作用。
