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[干洗工作场所使用的溶剂对健康影响的调查(报告2)。人体对四氯乙烯(TCE)的个人暴露及TCE水平]

[Investigation of health effects associated with solvents used in dry cleaning workplace (report 2). Personal exposure to tetrachloroethylene (TCE) and TCE levels in man].

作者信息

Hayashi M, Kitazume M, Yazawa A, Sato Y, Kawamura T

机构信息

Yokohama City Institute of Health.

出版信息

Nihon Koshu Eisei Zasshi. 1990 Mar;37(3):177-85.

PMID:2131979
Abstract

In order to understand the health effects of tetrachloroethylene (TCE) on dry cleaning workers, we surveyed personal exposure to TCE and TCE levels in man. Personal TCE exposure levels ranged from 0.6 to 100.8 ppm (time weighted average, TWA) and in winter the values were 1.1-11 times higher than that in summer. TCE levels in expired air ranged from 0.3 to 87 ppm, in blood from 0.01 to 0.73 micrograms/g, and total trichlorinated compounds (TTC) levels in urine ranged from 0.06 to 1.92 mg/dl. Correlation was highly significant between TCE concentration in blood and TTC concentration in urine (r = 0.927, p less than 0.01), and between concentration of personal exposure to TCE and TTC concentration in urine (r = 0.815, p less than 0.01). Following a three day holiday (non-exposure duration, 90 hr) TCE level in blood decreased from 0.05 to 0.006 micrograms/g, in expired air from 1.0 to 0.3 ppm and in TTC level in urine from 0.24 to 0.08 mg/dl respectively.

摘要

为了解四氯乙烯(TCE)对干洗工人健康的影响,我们调查了个人对TCE的接触情况以及人体中的TCE水平。个人TCE接触水平范围为0.6至100.8 ppm(时间加权平均值,TWA),且冬季的值比夏季高1.1至11倍。呼出气体中的TCE水平范围为0.3至87 ppm,血液中的TCE水平为0.01至0.73微克/克,尿液中的总三氯化合物(TTC)水平范围为0.06至1.92毫克/分升。血液中TCE浓度与尿液中TTC浓度之间(r = 0.927,p < 0.01)以及个人对TCE的接触浓度与尿液中TTC浓度之间(r = 0.815,p < 0.01)的相关性非常显著。在三天假期(非接触时长90小时)后,血液中的TCE水平分别从0.05降至0.006微克/克,呼出气体中的TCE水平从1.0降至0.3 ppm,尿液中的TTC水平从0.24降至0.08毫克/分升。

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