Marconato Laura, Stefanello Damiano, Valenti Paola, Bonfanti Ugo, Comazzi Stefano, Roccabianca Paola, Caniatti Mario, Romanelli Giorgio, Massari Federico, Zini Eric
Clinica Veterinaria L'Arca, Vico Cacciottoli 46-47, 80129 Naples, Italy.
J Am Vet Med Assoc. 2011 Feb 15;238(4):480-5. doi: 10.2460/javma.238.4.480.
To determine factors predicting survival in dogs with high-grade multicentric lymphoma. Design-Retrospective cohort study. Animals-127 dogs with high-grade multicentric lymphoma evaluated at 4 veterinary hospitals from 2000 to 2009.
Records were reviewed to identify dogs with completely staged high-grade multicentric lymphoma treated with chemotherapy. Data collected included signalment, history, hematologic findings, tumor characteristics, treatment, and outcome. Long-term survival was defined as surviving > 2 years after diagnosis. Variables were analyzed for associations with dogs living > 2 years.
Among the 127 enrolled dogs, 13 (10%) survived > 2 years with a median survival time of 914 days (range, 740 to 2,058 days). Survival rates at 3, 4, and 5 years were 4%, 3%, and 1 %, respectively. At diagnosis, 11 of the 13 long-term survivors had a body weight ≥ 10 kg, PCV ≥ 35%, absence of ionized hypercalcemia, centroblastic lymphoma, immunophenotype B, absence of bone marrow involvement, and lymphoma stages I through IV and were not previously treated with corticosteroids. The same combination of factors was present in 26 of 114 (23%) dogs surviving ≤ 2 years, yielding a negative predictive value of 97.8% for long-term survivors. Four of the 6 long-term survivors that died during the study died of another cancer; 3 of them had osteosarcoma.
Absence of the aforementioned combination of variables at diagnosis may help identify dogs with lymphoma that will not survive > 2 years. Other types of neoplasia, in particular osteosarcoma, may develop in long-term-surviving dogs.
确定影响高级别多中心性淋巴瘤犬生存的预测因素。设计-回顾性队列研究。动物-2000年至2009年在4家兽医医院评估的127只患有高级别多中心性淋巴瘤的犬。
回顾记录以识别接受化疗的完全分期高级别多中心性淋巴瘤犬。收集的数据包括信号、病史、血液学检查结果、肿瘤特征、治疗和结局。长期生存定义为诊断后存活超过2年。分析变量与存活超过2年的犬之间的关联。
在127只登记的犬中，13只（10%）存活超过2年，中位生存时间为914天（范围740至2058天）。3年、4年和5年生存率分别为4%、3%和1%。诊断时，13只长期存活者中有11只体重≥10kg，红细胞压积≥35%，无离子化高钙血症，中心母细胞性淋巴瘤，免疫表型B，无骨髓受累，淋巴瘤分期为I至IV期，且此前未接受过皮质类固醇治疗。114只存活≤2年的犬中有26只（23%）存在相同的因素组合，长期存活者的阴性预测值为97.8%。研究期间死亡的6只长期存活者中有4只因另一种癌症死亡；其中3只患有骨肉瘤。
诊断时不存在上述变量组合可能有助于识别存活时间不超过2年的淋巴瘤犬。其他类型的肿瘤，尤其是骨肉瘤，可能在长期存活的犬中发生。
