表观遗传学遗传：无可争议？
Epigenetic inheritance: uncontested?
机构信息
National Institute of Biological Sciences, Beijing 102206, China.
出版信息
Cell Res. 2011 Mar;21(3):435-41. doi: 10.1038/cr.2011.26. Epub 2011 Feb 15.
Abstract
"Epigenetics" is currently defined as "the inheritance of variation (-genetics) above and beyond (epi-) changes in the DNA sequence". Despite the fact that histones are believed to carry important epigenetic information, little is known about the molecular mechanisms of the inheritance of histone-based epigenetic information, including histone modifications and histone variants. Here we review recent progress and discuss potential models for the mitotic inheritance of histone modifications-based epigenetic information.
摘要
“表观遗传学”目前被定义为“超越 DNA 序列变化（epi-）的遗传变异（-genetics）”。尽管组蛋白被认为携带重要的表观遗传信息，但关于组蛋白为基础的表观遗传信息的分子机制，包括组蛋白修饰和组蛋白变体的遗传，人们知之甚少。在这里，我们回顾了最近的进展，并讨论了基于组蛋白修饰的表观遗传信息有丝分裂遗传的潜在模型。
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