Dean J D, Owens D R, Matthews S B
Department of Medicine, University of Wales College of Medicine, Heath Park, Cardiff.
Diabetes Res. 1990 Sep;15(1):21-5.
Fasting total cholesterol (TC), triglycerides (TG), HDL cholesterol (HDL C), apolipoprotein A1 (apo A1) and apolipoprotein B (apo B) were measured in 35 non-insulin dependent diabetic patients treated by diet with or without sulphonylureas and 35 control subjects matched for age, sex, and body mass index. Ratios of apolipoprotein and lipid were calculated. The diabetics were well controlled with a mean (+/- SD) glycosylated haemoglobin (HbA1) of 8.5 +/- 1.3% (normal range less than 8%). Compared to non-diabetic control subjects apo A1: HDL C, apo B: TC, and apo B: calculated LDL C were significantly higher in the NIDDM patients, (112.9 +/- 26.3 vs 83.0 +/- 28.7, p less than 0.001, 15.89 +/- 1.68 vs 14.22 +/- 3.48, p less than 0.01, and 24.32 +/- 3.19 vs 22.33 +/- 5.49, p less than 0.05 respectively). These findings reflect differences in cholesterol content in the absence of differences in apolipoprotein concentrations between the NIDDM and control groups. The cardiovascular risk ratio HDL C: non HDL C was significantly lower in the NIDDM patients (0.25 +/- 0.09 vs 0.31 +/- 0.15, p less than 0.01), but there was no difference in apo A1:apo B (1.42 +/- 0.42 vs 1.43 +/- 0.52, NS). Although apo A1: apo B correlated well with HDL C:non HDL C in both NIDDM and controls (r = 0.88, 0.72, p less than 0.001 respectively) the slope of the relationships differed b = 4.01 NIDDM vs 2.50 controls (95% confidence intervals for difference is 0.22-2.78). Simple widely available methods can identify abnormalities of lipoprotein content in treated NIDDM patients. Both HDL and LDL contain less cholesterol.(ABSTRACT TRUNCATED AT 250 WORDS)
对35例接受饮食治疗（无论是否使用磺脲类药物）的非胰岛素依赖型糖尿病患者以及35例年龄、性别和体重指数相匹配的对照者，测定其空腹总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、载脂蛋白A1（apo A1）和载脂蛋白B（apo B）。计算载脂蛋白与脂质的比值。糖尿病患者血糖控制良好，糖化血红蛋白（HbA1）平均（±标准差）为8.5±1.3%（正常范围小于8%）。与非糖尿病对照者相比，非胰岛素依赖型糖尿病患者的apo A1:HDL-C、apo B:TC和apo B:计算的低密度脂蛋白胆固醇（LDL-C）显著更高（分别为112.9±26.3对83.0±28.7，p<0.001；15.89±1.68对14.22±3.48，p<0.01；24.32±3.19对22.33±5.49，p<0.05）。这些发现反映了非胰岛素依赖型糖尿病组与对照组在载脂蛋白浓度无差异的情况下胆固醇含量的差异。非胰岛素依赖型糖尿病患者的心血管风险比HDL-C:非HDL-C显著更低（0.25±0.09对0.31±0.15，p<0.01），但apo A1:apo B无差异（1.42±0.42对1.43±0.52，无统计学意义）。尽管在非胰岛素依赖型糖尿病患者和对照者中apo A1:apo B与HDL-C:非HDL-C均显著相关（r分别为0.88、0.72，p<0.001），但两者关系的斜率不同（非胰岛素依赖型糖尿病患者b = 4.01，对照者b = 2.50，差异的95%置信区间为0.22 - 2.78）。简单且广泛可用的方法可识别接受治疗的非胰岛素依赖型糖尿病患者脂蛋白含量的异常。高密度脂蛋白和低密度脂蛋白所含胆固醇均较少。（摘要截短于250字）
