al-Muhtaseb N, al-Yuosuf A R, Bajaj J S
Department of Medicine, Faculty of Medicine, Kuwait University.
Acta Diabetol Lat. 1991 Jan-Mar;28(1):61-9. doi: 10.1007/BF02732115.
Plasma lipids, lipoproteins and apolipoproteins (apo) were analysed in 30 young Arab IDDM and 50 young insulin-requiring NIDDM women. The mean age of IDDM and NIDDM groups was 20.2 and 34.5 years, and mean duration of diabetes was 5.7 and 4.6 years, respectively. Two groups of 40 and 60 healthy women (matched for age and BMI) provided corresponding control groups. In comparison with control subjects, diabetics showed marked increases in the following parameters: total cholesterol (TC), low density lipoprotein (LDL) cholesterol, total triglycerides (TG), very low density lipoprotein (VLDL) triglycerides, phospholipids, apoB, LDL apoB, glucose and glycosylated hemoglobin (HbA1c) as well as the ratios of total cholesterol/high density lipoprotein (HDL) cholesterol, LDL-cholesterol/HDL-cholesterol, LDL cholesterol/high density lipoprotein (HDL) cholesterol, LDL-cholesterol/HDL-cholesterol, LDL cholesterol/high density lipoprotein 2 (HDL2) cholesterol and apoB/apoAI. Plasma LCAT activity, concentrations of HDL3 apoAI and apoAII in plasma and lipoprotein fractions were normal in both the diabetic groups. Levels of C-peptide, HDL, HDL2 and HDL3 cholesterol, plasma apoAI, HDL apoAI and HDL2 apoAI were markedly decreased in the diabetic groups as compared to their corresponding controls. There was no significant correlation between fasting glucose or HbA1c and any of the above parameters. Despite insulin therapy in both the diabetic groups studied, abnormalities in lipids, apoB and apoAI still persisted. Our data suggest a possible higher risk of atherosclerosis in these patients.
对30名年轻的阿拉伯胰岛素依赖型糖尿病（IDDM）女性和50名年轻的需要胰岛素治疗的非胰岛素依赖型糖尿病（NIDDM）女性进行了血浆脂质、脂蛋白和载脂蛋白（apo）分析。IDDM组和NIDDM组的平均年龄分别为20.2岁和34.5岁，糖尿病平均病程分别为5.7年和4.6年。两组分别有40名和60名健康女性（年龄和体重指数匹配）作为相应的对照组。与对照组相比，糖尿病患者在以下参数上显著升高：总胆固醇（TC）、低密度脂蛋白（LDL）胆固醇、总甘油三酯（TG）、极低密度脂蛋白（VLDL）甘油三酯、磷脂、apoB、LDL apoB、葡萄糖和糖化血红蛋白（HbA1c），以及总胆固醇/高密度脂蛋白（HDL）胆固醇、LDL胆固醇/HDL胆固醇、LDL胆固醇/HDL胆固醇、LDL胆固醇/HDL胆固醇、LDL胆固醇/高密度脂蛋白2（HDL2）胆固醇和apoB/apoAI的比值。两个糖尿病组的血浆卵磷脂胆固醇酰基转移酶（LCAT）活性、血浆和脂蛋白组分中HDL3 apoAI和apoAII的浓度均正常。与相应对照组相比，糖尿病组的C肽、HDL、HDL2和HDL3胆固醇水平、血浆apoAI、HDL apoAI和HDL2 apoAI水平显著降低。空腹血糖或HbA1c与上述任何参数之间均无显著相关性。尽管所研究的两个糖尿病组均接受了胰岛素治疗，但脂质、apoB和apoAI的异常仍然存在。我们的数据表明这些患者可能有更高的动脉粥样硬化风险。
