Zhao Shi-Yong, Yu Xin, Qiu Hai-Xia, Huang Nai-Yan, Wang Tian-Shi, Xue Ping, Gu Ying
School of Optoelectronics, Beijing Institute of Technology, Beijing 100081, China.
Guang Pu Xue Yu Guang Pu Fen Xi. 2010 Dec;30(12):3347-50.
Optical coherence tomography is an appropriate imaging method for biomedical science, due to its advantages of noninvasive nature, high resolution and fast imaging speed. Because most biological tissues have the characteristic of high scattering coefficient, OCT system can just obtain the structural images several millimeters below the surface of the tissues. The superficial depth of OCT's penetration limits application in dermatology field. As a common disease, the port wine stain (PWS) is a indication of OCT, because of its superficial lesion and significant expansion of blood vessels. To get deeper penetration in the skin, the authors employed 1 310 nm superluminescent diode as light source, optimized the light intensity ratio of reference delay arm and sample arm and control polarization, and the research of PWS imaging in vivo was accomplished. Besides, OCT is able to gather clear image and key characteristic parameters, such as the depth of epidermis layer, the diameter of blood vessel, etc. OCT will play an important role in the diagnosis and therapy of PWS.
光学相干断层扫描是生物医学领域一种合适的成像方法，因其具有非侵入性、高分辨率和快速成像速度等优点。由于大多数生物组织具有高散射系数的特性，光学相干断层扫描系统只能获取组织表面以下几毫米处的结构图像。光学相干断层扫描的穿透深度较浅，限制了其在皮肤科领域的应用。鲜红斑痣（PWS）作为一种常见疾病，因其病变表浅且血管显著扩张，是光学相干断层扫描的一个适应症。为了在皮肤中获得更深的穿透深度，作者采用1310纳米超发光二极管作为光源，优化了参考延迟臂和样品臂的光强比并控制偏振，完成了鲜红斑痣的体内成像研究。此外，光学相干断层扫描能够收集清晰的图像和关键特征参数，如表皮层深度、血管直径等。光学相干断层扫描将在鲜红斑痣的诊断和治疗中发挥重要作用。
