Latrive A, Teixeira L R C, Gomes A S L, Zezell D M
Center for Lasers and Applications - CLA, IPEN-CNEN/SP, São Paulo, Brazil.
Facial Care Centre - CADEFI, IMIP, Recife, PE, Brazil.
Skin Res Technol. 2016 May;22(2):223-9. doi: 10.1111/srt.12253. Epub 2015 Sep 3.
Port-Wine Stains (PWS) are vascular malformations of the dermis, whereas hemangiomas are vascular tumors usually present at birth. Early non-invasive diagnosis of the vascular lesion would greatly increase treatment efficiency. We propose to use optical coherence tomography (OCT), a morphological imaging technique, coupled with functional blood-flow Doppler modality.
We imaged lesions from five patients: one with PWS, four with hemangiomas, using a Thorlabs Swept-Source OCT system at 1325 nm. Additional Doppler images allow for distinguishing blood vessels from empty cavities that appear similar on conventional OCT images.
We are able to distinguish between normal skin and vascular lesions. The PWS lesion presents blood vessels of mean diameter 114 μm with a standard deviation of 92 μm, and mean depth 304 μm with a standard deviation of 99 μm. The hemangiomas present blood vessels of mean diameter 39 μm with a standard deviation of 19 μm, and mean depth 298 μm with a standard deviation of 133 μm.
We show a significant difference between the vascular characteristics of the studied PWS and hemangiomas lesions. We believe that OCT complemented by Doppler OCT could be a promising method for future non-invasive diagnosis and monitoring of some vascular lesions.
葡萄酒色斑（PWS）是真皮层的血管畸形，而血管瘤是通常在出生时就存在的血管肿瘤。对血管病变进行早期非侵入性诊断将大大提高治疗效率。我们建议使用光学相干断层扫描（OCT），一种形态成像技术，并结合功能性血流多普勒模式。
我们使用Thorlabs扫频源OCT系统在1325nm波长下对五名患者的病变进行成像：一名患有PWS，四名患有血管瘤。额外的多普勒图像有助于区分血管和在传统OCT图像上看起来相似的空洞。
我们能够区分正常皮肤和血管病变。PWS病变中的血管平均直径为114μm，标准差为92μm，平均深度为304μm，标准差为99μm。血管瘤中的血管平均直径为39μm，标准差为19μm，平均深度为298μm，标准差为133μm。
我们发现所研究的PWS和血管瘤病变的血管特征存在显著差异。我们认为，由多普勒OCT辅助的OCT可能是未来对某些血管病变进行非侵入性诊断和监测的一种有前景的方法。
