[Influence of different blood purification treatment on the serum leptin and neuropeptide Y levels in patients with chronic renal failure].

AIM

To study the influence of different blood purification technology on plasma leptin and neuropeptide Y (NPY).

METHODS

150 patients with chronic renal failure in our hospital were included, which were divided into hemodialysis (HD) group, hemoperfusion (HP) group, and hemofiltration (HF) group. The serum leptin and neuropeptide Y levels were measured by radioimmunoassay (RIA) before and after first treatment, after treatment for 3, 6 month.

RESULTS

Serum leptin and NPY were significantly lower after HDF and HP (P < 0.05), but not after HD in single treatment and for 3, 6 months treatment (P > 0.05). Serum leptin and NPY in group HDF and HP patients in single treatment and for 3, 6 months treatment were significantly greater than those of group HD (P < 0.05). The clearance rate of leptin and NPY in group HDF and HP patients were significantly greater than those of group HD (P < 0.05). There is no correlation between serum leptin and NPY (P > 0.05).

CONCLUSION

Hemodialysis can not lower serum leptin and NPY. But HDF and HP can eliminate serum leptin and NPY preferably, which may improve the patients' nutritional status.