Bellei E, Roncada P, Pisoni L, Joechler M, Zaghini A
Veterinary Clinical Department, Faculty of Veterinary Medicine, Alma Mater Studiorum, University of Bologna, Bologna, Italy.
J Vet Pharmacol Ther. 2011 Oct;34(5):437-41. doi: 10.1111/j.1365-2885.2010.01263.x. Epub 2011 Feb 17.
Objectives of this study were to evaluate plasma concentrations and analgesic efficacy of fentanyl administered transdermically in dogs undergoing spinal surgery. At the end of the surgery and before awakening, a fentanyl-patch was applied and was maintained in situ for 72 h. Blood samples were taken before the application of the patch, at 2, 4, 6, 8, 10, 12, 18, 24, 32, 40, 48, 60, and 72 h after application and then 2, 4, 6, 8, 10, and 12 h after its removal. Before each blood sampling, pain evaluation was carried out using the Glasgow pain score, appropriately modified. Plasma concentrations of fentanyl were determined using a specific immuno-enzymatic kit. In this study, the minimum analgesic plasma concentration (0.23 ng/mL) required to achieve analgesia in human and considered to apply also for dogs was reached in all animals. No animal showed pain in the range of 'intense pain'; in two cases, the level of the pain was slight or moderate. No undesired effects were found. Results suggest that the use of transdermic patches could represent a valid aid in pain therapy in small animals; in particular, it contributes to the postoperative well-being of patients undergoing major surgery.
本研究的目的是评估芬太尼经皮给药在接受脊柱手术的犬类中的血浆浓度和镇痛效果。在手术结束且动物未苏醒前，应用芬太尼透皮贴剂，并原位保留72小时。在贴剂应用前、应用后2、4、6、8、10、12、18、24、32、40、48、60和72小时以及移除后2、4、6、8、10和12小时采集血样。每次采血前，使用适当修改后的格拉斯哥疼痛评分进行疼痛评估。使用特定的免疫酶试剂盒测定芬太尼的血浆浓度。在本研究中，所有动物均达到了在人类中实现镇痛所需的最低镇痛血浆浓度（0.23 ng/mL），并认为该浓度也适用于犬类。没有动物表现出“剧烈疼痛”范围内的疼痛；在两例中，疼痛程度为轻度或中度。未发现不良影响。结果表明，透皮贴剂的使用可能是小动物疼痛治疗的有效辅助手段；特别是，它有助于接受大手术患者的术后康复。
