Department of Veterinary Medicine, University of Bari "Aldo Moro", Bari, Italy.
Vet Med Sci. 2022 Mar;8(2):469-475. doi: 10.1002/vms3.691. Epub 2021 Dec 24.
The purpose of the present study was to evaluate the postoperative analgesic efficacy of fentanyl patches versus subcutaneous tramadol after canine ovariectomy, with and without unilateral mastectomy.
A total of 40 female dogs were included in the present study, all of which were domesticated, healthy and 4-12 years of age. The animals were divided into four groups (n = 10 per group) based on the surgery and the analgesic protocol used: the TO group only underwent ovariectomy, and received postoperative tramadol; the TM group underwent both ovariectomy and mastectomy, and received postoperative tramadol; the FO group only underwent ovariectomy, and received fentanyl patches; and the FM group underwent both ovariectomy and mastectomy, and received fentanyl patches. Postoperative pain was evaluated every 4 h for 24 h using a numeric analogue scale (NAS) and a modified Glasgow Composite Measure Pain Scale Short Form (CMPS-SF).
The results of the present study showed that patients in all four groups tolerated postoperative surgical stress well. Analysis of variance for repeated measures did not show significant differences in the NAS scores and in Glasgow CMPS-SF between groups in terms of pain scores or rescue analgesia.
These results indicated that the analgesic effect of the fentanyl patch was similar to that of subcutaneous (SC) tramadol in female dogs after ovariectomy, with and without unilateral mastectomy, suggesting that the fentanyl patch may represent a valid supplementary tool for the control of postoperative pain in animals after surgery.
本研究旨在评估芬太尼贴剂与皮下曲马多在犬卵巢切除术后镇痛的效果,包括单侧乳房切除术和不进行乳房切除术的情况。
本研究共纳入 40 只雌性犬,均为家养、健康且 4-12 岁。根据手术和使用的镇痛方案,将动物分为四组(每组 10 只):TO 组仅行卵巢切除术,术后给予曲马多;TM 组行卵巢切除术和乳房切除术,术后给予曲马多;FO 组仅行卵巢切除术,术后给予芬太尼贴剂;FM 组行卵巢切除术和乳房切除术,术后给予芬太尼贴剂。术后 24 小时内,每 4 小时使用数字模拟评分法(NAS)和改良格拉斯哥复合疼痛量表短表(CMPS-SF)评估术后疼痛。
本研究结果显示,所有四组患者均能很好地耐受术后手术应激。重复测量方差分析显示,在疼痛评分或解救性镇痛方面,各组之间的 NAS 评分和格拉斯哥 CMPS-SF 评分均无显著差异。
这些结果表明,芬太尼贴剂在犬卵巢切除术后镇痛的效果与皮下(SC)曲马多相似,无论是否进行单侧乳房切除术,这表明芬太尼贴剂可能是术后动物控制术后疼痛的有效补充工具。