Department of Prosthodontics, LSU Health Sciences Center School of Dentistry, New Orleans, LA, USA.
J Oral Rehabil. 2011 Sep;38(9):686-90. doi: 10.1111/j.1365-2842.2011.02206.x. Epub 2011 Feb 17.
The objective was to engineer an inexpensive intraoral removable denture system for rodents that can be utilised in numerous oral health research applications. At the forefront is biofilm research related to Candida-associated denture stomatitis. Previously described intraoral devices are primitive and inadequate. The denture system was engineered consisting of a fixed part that is anchored to the posterior palate by orthodontic wires and acrylic resin and a removable part fitted to the anterior palate that is retained by magnets embedded in the fixed part. Both parts are custom fitted to the rodent palate by impression making and cast fabrication. Rats fitted with the intraoral denture system maintained body weight and normal activity with the device maintaining integrity and durability for upwards of 8 weeks. The denture system was used successfully to establish a working model of denture stomatitis. This newly engineered inexpensive intraoral removable denture system for rodents can be utilised in numerous oral health research applications, including denture-associated infections, biofilms and a variety of biomaterial applications. The removable portion is advantageous for longitudinal analyses and charging/discharging of biomaterials.
目的是为啮齿动物设计一种廉价的口腔内可移动义齿系统，可用于多种口腔健康研究应用。处于前沿的是与念珠菌相关的义齿性口炎相关的生物膜研究。以前描述的口腔内装置是原始的和不充分的。义齿系统由固定部分和可移动部分组成，固定部分通过正畸丝和丙烯酸树脂固定在后腭，可移动部分贴合在前腭，由固定部分嵌入的磁铁固定。这两部分都是通过印模和铸造制作来定制适配啮齿动物的腭部。大鼠佩戴口腔内义齿系统后，在装置保持完整性和耐用性长达 8 周的情况下，保持体重和正常活动。该义齿系统成功地用于建立义齿性口炎的工作模型。这种新设计的廉价啮齿动物口腔内可移动义齿系统可用于多种口腔健康研究应用，包括与义齿相关的感染、生物膜和各种生物材料应用。可移动部分有利于进行纵向分析和生物材料的充放电。
