ZBED6：胎盘哺乳动物共同祖先中一种新转录因子的诞生。
ZBED6: The birth of a new transcription factor in the common ancestor of placental mammals.
作者信息
Andersson Leif, Andersson Göran, Hjälm Göran, Jiang Lin, Lindblad-Toh Kerstin, Lindroth Anders M, Markljung Ellen, Nyström Anna-Maja, Rubin Carl-Johan, Sundström Elisabeth
机构信息
Department of Medical Biochemistry and Microbiology; Uppsala University; Uppsala, Sweden.
出版信息
Transcription. 2010 Nov;1(3):144-148. doi: 10.4161/trns.1.3.13343. Epub 2010 Aug 17.
Abstract
A DNA transposon integrated into -the genome of a primitive mammal some 200 million years ago and, millions of years later, it evolved an essential function in the common ancestor of all placental mammals. This protein, now named ZBED6, was recently discovered because a mutation disrupting one of its binding sites, in an intron of the IGF2 gene, makes pigs grow more muscle. These findings have revealed a new mechanism for regulating muscle growth as well as a novel transcription factor that appears to be of major importance for transcriptional regulation in placental mammals.
摘要
大约2亿年前，一个DNA转座子整合到一种原始哺乳动物的基因组中，数百万年后，它在所有胎盘哺乳动物的共同祖先中进化出了一种重要功能。这种蛋白质现在被命名为ZBED6，最近被发现是因为在IGF2基因的一个内含子中，一个破坏其结合位点之一的突变使猪长出了更多肌肉。这些发现揭示了一种调节肌肉生长的新机制，以及一种新的转录因子，它似乎对胎盘哺乳动物的转录调控至关重要。
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本文引用的文献
1
Contrasts between adaptive coding and noncoding changes during human evolution.
Proc Natl Acad Sci U S A. 2010 Apr 27;107(17):7853-7. doi: 10.1073/pnas.0911249107. Epub 2010 Apr 12.
2
Five-vertebrate ChIP-seq reveals the evolutionary dynamics of transcription factor binding.
Science. 2010 May 21;328(5981):1036-40. doi: 10.1126/science.1186176. Epub 2010 Apr 8.
3
Transcriptional corepressor TLE1 functions with Runx2 in epigenetic repression of ribosomal RNA genes.
Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):4165-9. doi: 10.1073/pnas.1000620107. Epub 2010 Feb 16.
4
A domesticated transposon mediates the effects of a single-nucleotide polymorphism responsible for enhanced muscle growth.
EMBO Rep. 2010 Apr;11(4):305-11. doi: 10.1038/embor.2010.6. Epub 2010 Feb 5.
5
ZBED6, a novel transcription factor derived from a domesticated DNA transposon regulates IGF2 expression and muscle growth.
PLoS Biol. 2009 Dec;7(12):e1000256. doi: 10.1371/journal.pbio.1000256. Epub 2009 Dec 15.
6
Comparative genomics of gene regulation-conservation and divergence of cis-regulatory information.
Curr Opin Genet Dev. 2009 Dec;19(6):565-70. doi: 10.1016/j.gde.2009.10.006. Epub 2009 Nov 11.
7
Copy number variation in intron 1 of SOX5 causes the Pea-comb phenotype in chickens.
PLoS Genet. 2009 Jun;5(6):e1000512. doi: 10.1371/journal.pgen.1000512. Epub 2009 Jun 12.
8
ChIP-seq accurately predicts tissue-specific activity of enhancers.
Nature. 2009 Feb 12;457(7231):854-8. doi: 10.1038/nature07730.
9
Evo-devo and an expanding evolutionary synthesis: a genetic theory of morphological evolution.
Cell. 2008 Jul 11;134(1):25-36. doi: 10.1016/j.cell.2008.06.030.
10
Integration of external signaling pathways with the core transcriptional network in embryonic stem cells.
Cell. 2008 Jun 13;133(6):1106-17. doi: 10.1016/j.cell.2008.04.043.
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