组蛋白 H3 赖氨酸 27 三甲基化在植物发育中的动态变化。
Dynamics of histone H3 lysine 27 trimethylation in plant development.
机构信息
Department of Botany and Plant Sciences, Institute of Integrative Genome Biology, University of California, Riverside, CA 92521, USA.
出版信息
Curr Opin Plant Biol. 2011 Apr;14(2):123-9. doi: 10.1016/j.pbi.2011.01.001. Epub 2011 Feb 15.
Abstract
The development of multicellular organisms is governed partly by temporally and spatially controlled gene expression. DNA methylation, covalent modifications of histones, and the use of histone variants are the major epigenetic mechanisms governing gene expression in plant development. In this review, we zoom in onto histone H3 lysine 27 trimethylation (H3K27me3), a repressive mark that plays a crucial role in the dynamic regulation of gene expression in plant development, to discuss recent advances as well as outstanding questions in the deposition, recognition, and removal of the mark and the impacts of these molecular processes on plant development.
摘要
多细胞生物的发育部分受时间和空间控制的基因表达调控。DNA 甲基化、组蛋白的共价修饰以及组蛋白变体的使用是调控植物发育中基因表达的主要表观遗传机制。在这篇综述中，我们聚焦于组蛋白 H3 赖氨酸 27 三甲基化（H3K27me3），这是一种抑制性标记，在植物发育中基因表达的动态调控中起着关键作用，讨论了该标记的沉积、识别和去除以及这些分子过程对植物发育的影响方面的最新进展和悬而未决的问题。
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