植物发育过程中H3K27me3甲基化与去甲基化的动态变化
Dynamics of H3K27me3 methylation and demethylation in plant development.
作者信息
Gan Eng-Seng, Xu Yifeng, Ito Toshiro
机构信息
a Temasek Life Sciences Laboratory (TLL); 1 Research Link; National University of Singapore ; Singapore.
b Department of Biological Sciences ; Faculty of Science; National University of Singapore ; Singapore.
出版信息
Plant Signal Behav. 2015;10(9):e1027851. doi: 10.1080/15592324.2015.1027851.
Abstract
Epigenetic regulation controls multiple aspects of the plant development. The N-terminal tail of histone can be differently modified to regulate various chromatin activities. One of them, the trimethylation of histone H3 lysine 27 (H3K27me3) confers a repressive chromatin state with gene silencing. H3K27me3 is dynamically deposited and removed throughout development. While components of the H3K27me3 writer, Polycomb repressive complex 2 (PRC2), have been reported for almost 2 decades, it is only recently that JUMONJI (JMJ) proteins are reported as H3K27me3 demethylases, affirming the dynamic nature of histone modifications. This review highlights recent progress in plant epigenetic research, focusing on the H3K27me3 demethylases.
摘要
表观遗传调控控制着植物发育的多个方面。组蛋白的N端尾巴可以进行不同的修饰，以调节各种染色质活动。其中之一，组蛋白H3赖氨酸27（H3K27me3）的三甲基化赋予了一种具有基因沉默作用的抑制性染色质状态。H3K27me3在整个发育过程中动态沉积和去除。虽然组蛋白H3K27me3的写入蛋白、多梳抑制复合物2（PRC2）的组成成分已被报道近20年，但直到最近JUMONJI（JMJ）蛋白才被报道为H3K27me3去甲基化酶，这证实了组蛋白修饰的动态性质。本综述重点介绍了植物表观遗传学研究的最新进展，尤其关注H3K27me3去甲基化酶。
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