• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Extrapolation of toxic indices among test objects.测试对象间毒性指标的外推
Interdiscip Toxicol. 2010 Dec;3(4):137-9. doi: 10.2478/v10102-010-0054-7.
2
The Tubifex tubifex assay for the determination of acute toxicity.用于测定急性毒性的颤蚓试验。
Altern Lab Anim. 2007 May;35(2):229-37. doi: 10.1177/026119290703500210.
3
Interspecies quantitative structure-activity relationship model for aldehydes: aquatic toxicity.
Environ Toxicol Chem. 2004 Feb;23(2):463-70. doi: 10.1897/02-579.
4
Regression and cluster analysis of the acute toxicity of 267 chemicals to six species of biota and the octanol/water partition coefficient.267种化学物质对六种生物群落的急性毒性与正辛醇/水分配系数的回归和聚类分析
Sci Total Environ. 1991 Dec;109-110:499-514. doi: 10.1016/0048-9697(91)90204-r.
5
Relationships of quantitative structure-activity to comparative toxicity of selected phenols in the Pimephales promelas and Tetrahymena pyriformis test systems.在肥头鲦鱼和梨形四膜虫测试系统中，选定酚类的定量构效关系与比较毒性的关系。
Ecotoxicol Environ Saf. 1986 Oct;12(2):146-53. doi: 10.1016/0147-6513(86)90051-5.
6
CORAL: QSAR models for acute toxicity in fathead minnow (Pimephales promelas).CORAL：黑头呆鱼（肥头鲦鱼，Pimephales promelas）急性毒性的定量构效关系模型。
J Comput Chem. 2012 May 5;33(12):1218-23. doi: 10.1002/jcc.22953. Epub 2012 Feb 27.
7
A similarity-based QSAR model for predicting acute toxicity towards the fathead minnow (Pimephales promelas).一种基于相似性的定量构效关系模型，用于预测对黑头呆鱼（Pimephales promelas）的急性毒性。
SAR QSAR Environ Res. 2015;26(3):217-43. doi: 10.1080/1062936X.2015.1018938.
8
Toxicity of sediment-associated substituted phenylamine antioxidants on the early life stages of Pimephales promelas and a characterization of effects on freshwater organisms.沉积物相关的取代苯胺抗氧化剂对黑头软口鲦早期生命阶段的毒性及对淡水生物影响的特征描述
Environ Toxicol Chem. 2017 Oct;36(10):2730-2738. doi: 10.1002/etc.3828. Epub 2017 Jun 16.
9
Development of models to predict fish early-life stage toxicity from acute Daphnia magna toxicity.开发模型以预测鱼类早期生活阶段毒性，基于大型溞急性毒性数据。
SAR QSAR Environ Res. 2018 Sep;29(9):725-742. doi: 10.1080/1062936X.2018.1513423. Epub 2018 Sep 5.
10
Using probabilistic neural networks to model the toxicity of chemicals to the fathead minnow (Pimephales promelas): a study based on 865 compounds.使用概率神经网络对化学物质对黑头呆鱼（Pimephales promelas）的毒性进行建模：基于865种化合物的研究。
Chemosphere. 1999 Jun;38(14):3237-45. doi: 10.1016/s0045-6535(99)00553-6.

本文引用的文献

1
Validation of QSAR models for legislative purposes.用于立法目的的定量构效关系（QSAR）模型的验证
Interdiscip Toxicol. 2009 Sep;2(3):184-6. doi: 10.2478/v10102-009-0014-2. Epub 2009 Sep 28.
2
Primary rat hepatocytes in chemical testing and QSAR predictive applicability.用于化学测试和定量构效关系预测适用性的原代大鼠肝细胞。
Toxicol In Vitro. 2010 Feb;24(1):240-4. doi: 10.1016/j.tiv.2009.08.028. Epub 2009 Sep 6.
3
Acute toxicity estimation by calculation--Tubifex assay and quantitative structure-activity relationships.通过计算进行急性毒性评估——颤蚓试验与定量构效关系
Environ Toxicol Chem. 2008 Nov;27(11):2281-6. doi: 10.1897/08-037.1.
4
Inhalation toxicity studies: OECD guidelines in relation to REACH and scientific developments.吸入毒性研究：与《化学品注册、评估、授权和限制法规》相关的经合组织准则及科学进展
Exp Toxicol Pathol. 2008 Jun;60(2-3):125-33. doi: 10.1016/j.etp.2008.01.011. Epub 2008 May 1.
5
The Tubifex tubifex assay for the determination of acute toxicity.用于测定急性毒性的颤蚓试验。
Altern Lab Anim. 2007 May;35(2):229-37. doi: 10.1177/026119290703500210.
6
Acute systemic toxicity--prospects for tiered testing strategies.急性全身毒性——分层测试策略的前景
Toxicol In Vitro. 2004 Apr;18(2):227-30. doi: 10.1016/s0887-2333(03)00143-7.
7
Use of QSARs in international decision-making frameworks to predict ecologic effects and environmental fate of chemical substances.在国际决策框架中使用定量构效关系来预测化学物质的生态效应和环境归宿。
Environ Health Perspect. 2003 Aug;111(10):1376-90. doi: 10.1289/ehp.5759.
8
Methods for reliability and uncertainty assessment and for applicability evaluations of classification- and regression-based QSARs.基于分类和回归的定量构效关系（QSAR）的可靠性和不确定性评估方法以及适用性评估方法。
Environ Health Perspect. 2003 Aug;111(10):1361-75. doi: 10.1289/ehp.5758.
9
Summary of a workshop on regulatory acceptance of (Q)SARs for human health and environmental endpoints.关于人类健康和环境终点的（定量）构效关系（QSAR）监管认可研讨会总结
Environ Health Perspect. 2003 Aug;111(10):1358-60. doi: 10.1289/ehp.5757.
10
Interspecies modeling of narcotics toxicity to aquatic animals.麻醉品对水生动物毒性的种间建模。
Bull Environ Contam Toxicol. 2000 Sep;65(3):399-406. doi: 10.1007/s0012800141.

测试对象间毒性指标的外推

Extrapolation of toxic indices among test objects.

作者信息

Tichý Miloň, Rucki Marián, Roth Zdeněk, Hanzlíková Iveta, Vlková Alena, Tumová Jana, Uzlová Rút

机构信息

National Institute of Public Health, Šrobárova 48, 10042 Praha 10, Czech Republic.

出版信息

Interdiscip Toxicol. 2010 Dec;3(4):137-9. doi: 10.2478/v10102-010-0054-7.

DOI:10.2478/v10102-010-0054-7
PMID:21331180
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3035571/
Abstract

Oligochaeta Tubifex tubifex, fish fathead minnow (Pimephales promelas), hepatocytes isolated from rat liver and ciliated protozoan are absolutely different organisms and yet their acute toxicity indices correlate. Correlation equations for special effects were developed for a large heterogeneous series of compounds (QSAR, quantitative structure-activity relationships). Knowing those correlation equations and their statistic evaluation, one can extrapolate the toxic indices. The reason is that a common physicochemical property governs the biological effect, namely the partition coefficient between two unmissible phases, simulated generally by n-octanol and water. This may mean that the transport of chemicals towards a target is responsible for the magnitude of the effect, rather than reactivity, as one would assume suppose.

摘要

寡毛纲颤蚓、黑头呆鱼（肥头鲦鱼）、从大鼠肝脏分离出的肝细胞以及纤毛原生动物是完全不同的生物，但它们的急性毒性指数却相互关联。针对大量不同种类的化合物（定量构效关系，QSAR）建立了特效相关方程。了解这些相关方程及其统计评估后，就可以推断出毒性指数。原因在于一种共同的物理化学性质决定了生物效应，即两个不互溶相之间的分配系数，一般用正辛醇和水来模拟。这可能意味着化学物质向靶点的转运决定了效应的大小，而不是像人们通常假设的那样由反应活性决定。