Schultz T W, Holcombe G W, Phipps G L
Ecotoxicol Environ Saf. 1986 Oct;12(2):146-53. doi: 10.1016/0147-6513(86)90051-5.
The relative toxic response of 27 selected phenols in the 96-hr acute flowthrough Pimephales promelas (fathead minnow) and the 48- to 60-hr chronic static Tetrahymena pyriformis (ciliate protozoan) test systems was evaluated. Log Kow-dependent linear regression analyses revealed that the data from each test system consisted of two linear equations. The less toxic chemicals form a relationship which models polar narcosis; these chemicals are slightly more active than the baseline toxicity of nonionic narcotic chemicals. The more toxic chemicals form a relationship which models uncoupling of oxidative phosphorylation. Regression analysis of fathead minnow toxicity (log LC50 (mol/liter] vs Tetrahymena toxicity (log BR (mmol/liter] showed good correlation between the two systems. An exception appears to be 4-nitrophenol, which is more active in the Tetrahymena system than in the fathead minnow and lies outside the 95% confidence interval. Reanalysis following deletion of 4-nitrophenol results in the equation log LC50 = -0.9192 (log BR) -3.5035; n = 26, r2 = 0.887.
评估了27种选定酚类在96小时急性流水式黑头呆鱼（肥头鲤）试验系统和48至60小时慢性静态梨形四膜虫（纤毛原生动物）试验系统中的相对毒性反应。基于辛醇-水分配系数（Log Kow）的线性回归分析表明，每个试验系统的数据均由两个线性方程组成。毒性较小的化学物质形成一种模拟极性麻醉的关系；这些化学物质的活性略高于非离子麻醉性化学物质的基线毒性。毒性较大的化学物质形成一种模拟氧化磷酸化解偶联的关系。黑头呆鱼毒性（Log LC50 [mol/升]）与梨形四膜虫毒性（Log BR [mmol/升]）的回归分析表明，这两个系统之间具有良好的相关性。4-硝基苯酚似乎是个例外，它在梨形四膜虫系统中的活性高于黑头呆鱼，且不在95%置信区间内。删除4-硝基苯酚后重新分析得到方程Log LC50 = -0.9192（Log BR）-3.5035；n = 26，r2 = 0.887。
