4 周龄猪肺部黏膜表面黏蛋白的表达。
Expression of mucins on the mucosal surface of lungs of 4-week-old pigs.
机构信息
Department of Veterinary Pathology, College of Veterinary Medicine, Seoul National University, 599 Gwanak-ro, Gwanak-Gu, 151-742, Seoul, Republic of Korea.
出版信息
Vet Res Commun. 2011 Apr;35(4):255-60. doi: 10.1007/s11259-011-9465-y. Epub 2011 Feb 18.
The aim of this study was to determine the immunoreactivity of normal small bronchial, bronchiolar, respiratory bronchiolar, and interalveolar epithelium using antibodies to six mucins: MUC1, MUC2, MUC4, MUC5AC, MUC5B, and MUC6. The large, gel-forming secreted mucins MUC2, MUC5AC, and MUC5B were widely expressed in the lower respiratory tract. The results of this study demonstrate that these secreted mucins form a gel to cover and protect the mucosal surface in the lower respiratory tract of pigs.
本研究旨在使用针对六种粘蛋白的抗体来确定正常小支气管、细支气管、呼吸性细支气管和肺泡间上皮的免疫反应性：MUC1、MUC2、MUC4、MUC5AC、MUC5B 和 MUC6。大的、凝胶形成的分泌型粘蛋白 MUC2、MUC5AC 和 MUC5B 在呼吸道的下部广泛表达。本研究的结果表明，这些分泌型粘蛋白在猪的下呼吸道形成凝胶覆盖并保护黏膜表面。
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