Department of Ophthalmology, University of Tokyo School of Medicine, Tokyo, Japan.
Jpn J Ophthalmol. 2011 Jan;55(1):35-8. doi: 10.1007/s10384-010-0893-y. Epub 2011 Feb 18.
To investigate the utility values associated with visual loss due to age-related macular degeneration (AMD) in Japanese patients.
Utility values in 48 Japanese patients with bilateral exudative AMD were measured using the time trade-off and standard gamble methods.
The time trade-off method utility values correlated with the best-corrected visual acuity (BCVA) in the better-seeing eye. The estimated utility values according to the BCVA in the better-seeing eye were 0.534 (BCVA, 0.01-0.15), 0.574 (0.2-0.3), 0.613 (0.4-0.6), and 0.653 (0.7-1.0). The utility values obtained by the standard gamble method were not significantly correlated with BCVA in the better-seeing eye.
The present results concur with those of previous studies showing that AMD causes a substantial decrease in patient utility values. The utility values obtained in the current study provide important information for use in cost-utility analysis of interventions for Japanese AMD patients.
调查与年龄相关性黄斑变性(AMD)导致的视力丧失相关的效用值在日本患者中的情况。
使用时间权衡和标准博弈方法测量了 48 名双侧渗出性 AMD 日本患者的效用值。
时间权衡方法的效用值与较好眼的最佳矫正视力(BCVA)相关。根据较好眼的 BCVA 估计的效用值分别为 0.534(BCVA,0.01-0.15)、0.574(0.2-0.3)、0.613(0.4-0.6)和 0.653(0.7-1.0)。标准博弈方法获得的效用值与较好眼的 BCVA 无显著相关性。
本研究结果与以往研究一致,表明 AMD 会导致患者效用值显著下降。本研究中获得的效用值为日本 AMD 患者干预措施的成本效用分析提供了重要信息。